E-55888 is a drug developed by Esteve, which acts as a potent and selective full agonist at the 5HT₇ serotonin receptor, and is used for investigating the role of 5-HT₇ receptors in the perception of pain. When administered by itself, E-55888 is anti-hyperalgesic but not analgesic, but when administered alongside morphine, E-55888 was found to significantly increase the analgesic effects.

Jonathan Smith (born January 27, 1971), better known by his stage name Lil Jon, is an American rapper, music producer, entrepreneur, and international DJ who was a member of the group Lil Jon & The East Side Boyz. Lil Jon formed the group in 1997, and the group released several albums between then and 2004. He then went solo and released a new album in 2010 called Crunk Rock.

Lil' Jon was born and raised in Atlanta, Georgia. He graduated from Frederick Douglass High School.

After working as a DJ for Atlanta night clubs, he started working for So So Def Recordings between 1993 and 2000. The group signed to the Atlanta-based Mirror Image Records and were distributed by Ichiban Records. In 1997, Lil' Jon & the East Side Boyz debuted with Get Crunk, Who U Wit: Da Album. It included singles "Who U Wit?" and "Shawty Freak a Lil' Sumthin'", the latter of which came out in 1998. Both singles charted on the Billboard Hot R&B/Hip-Hop Songs chart at No. 70 and No. 62 respectively. In 2000 Jon took part in starting up his own label BME Recordings and signed a distribution agreement with Norcross, Georgia based Southern Music Distribution. There he released his break through album titled We Still Crunk. Among the tracks on that project was the hit single "I Like Dem Girlz", which reached No. 55 on the R&B chart and No. 3 on the Hot Rap Tracks chart.