Amfonelic acid (AFA; WIN 25,978; Oxaprozin) is a drug used in scientific studies. It was discovered while researchers were investigating novel antibiotics.In studies it was found a potent and highly selective dopamine reuptake inhibitor (DRI) in rat brain preparations. A study found a moderately long half-life of approximately 12 hours and a dopaminergic potency approximately 50 fold that of methylphenidate in rat brain preparations.