- published: 08 Oct 2011
- views: 11834
Ammonium acetate is a chemical compound with the formula NH4CH3CO2. It is a white, hygroscopic solid and can be derived from the reaction of ammonia and acetic acid. It is available commercially.
It is the main precursor to acetamide:
It is also used as a diuretic.
As the salt of a weak acid and a weak base, ammonium acetate is often used with acetic acid to create a buffer solution. Ammonium acetate is volatile at low pressures. Because of this, it has been used to replace cell buffers with non-volatile salts in preparing samples for mass spectrometry. It is also popular as a buffer for mobile phases for HPLC with ELSD detection for this reason. Other volatile salts that have been used for this include ammonium formate.