- published: 06 Jan 2014
- views: 13440
Prostaglandin-endoperoxide synthase 2, also known as cyclooxygenase-2 or simply COX-2, is an enzyme that in humans is encoded by the PTGS2 gene.
COX-2 was discovered in 1991 by the Daniel Simmons laboratory at Brigham Young University.
COX-2 exists as a homodimer, each monomer with a molecular mass of about 70 kDa. The tertiary and quaternary structures of COX-1 and COX-2 enzymes are almost identical. Each subunit has three different structural domains: a short N-terminal epidermal growth factor (EGF) domain; an α-helical membrane-binding moiety; and a C-terminal catalytic domain. COX enzymes are monotopic membrane proteins; the membrane-binding domain consists of a series of amphipathic α helices with several hydrophobic amino acids exposed to a membrane monolayer. COX-1 and COX-2 are bifunctional enzymes that carry out two consecutive chemical reactions in spatially distinct but mechanistically coupled active sites. Both the cyclooxygenase and the peroxidase active sites are located in the catalytic domain, which accounts for approximately 80% of the protein. The catalytic domain is homologous to mammalian peroxidases such as myeloperoxidase.
Carl Cox (born 29 July 1962, Barbados) is a British techno and house music DJ and producer.
Cox grew up in Oldham, Lancashire, before attending Glastonbury High Boys secondary modern school on Glastonbury Road in Morden.[citation needed] Cox began his career as a hardcore and rave DJ in the mid 1980s. One of the first gigs he played was in legendary promoters John Binton and Terry Onion's Squeeze my buttered Onions! club in Hackney, London Unconfirmed reports suggest he was coerced into swallowing an onion on stage, one of Terry's famous requests he gave to his acts. He was named the "Three Deck Wizard" after playing on three turntables simultaneously at the Second Summer of Love in 1988.[citation needed] He has performed at clubs such as The Eclipse, Edge, Shelly's, Sterns Nightclub, Heaven, Sir Henry's in Cork, Ireland and Angels and The Haçienda, as well as raves for Fantazia, Dreamscape, and Amnesia House. He now spearheads two record labels, Intec Records and 23rd Century Records. He also has his own stage every year at Ultra Music Festival called Carl Cox and Friends.
cox1 cox2
Cox 2 Inhibitors NSAIDS
Dr. Fuchs on Aspirin and Targeting COX-2 in Colorectal Cancer
Dr. Doom on Cox-2 Inhibitors.MP4
A Bad Idea // Scary Game Squad - Until Dawn Part 2
Best Of Dr. Cox 2
Simple Simon Animated - Jesse Cox #2 - Breaking Fast
Scrubs- best of Dr.Cox 2 [German]
Patrick Cox - 2 Broke Girls (better quality)
SOLOS DE NITA STRAUSS E COURTNEY COX 2
Gestatten, mein Name ist Cox (2/4)
TotalBiscuit and Jesse Cox Play Terraria - Part 2 - Jesse is "turable" at mental arithmetic
Carl Cox 2
Firewatch [Part 2] - That Damn Chelsea