Pope Clement I (fl. 96), also known as Saint Clement of Rome (in Latin, Clemens Romanus), is listed from an early date as a Bishop of Rome. He was the first Apostolic Father of the Church.

Few details are known about Clement's life. According to Tertullian, Clement was consecrated by Saint Peter, and he is known to have been a leading member of the church in Rome in the late 1st century. Early church lists place him as the second or third bishop of Rome after Saint Peter. The Liber Pontificalis presents a list that makes Pope Linus the second in the line of bishops of Rome, with Peter as first; but at the same time it states that Peter ordained two bishops, Linus and Pope Cletus, for the priestly service of the community, devoting himself instead to prayer and preaching, and that it was to Clement that he entrusted the Church as a whole, appointing him as his successor. Tertullian too makes Clement the immediate successor of Peter. And while in one of his works Jerome gives Clement as "the fourth bishop of Rome after Peter" (not in the sense of fourth successor of Peter, but fourth in a series that included Peter), he adds that "most of the Latins think that Clement was second after the apostle". Clement is put after Linus and Cletus/Anacletus in the earliest (c. 180) account, that of Irenaeus, who is followed by Eusebius of Caesarea. The meaning of these early reports is unclear, given the lack of evidence for monarchical episcopacy in Rome at so early a date.

Clement VII (26 May 1478 – 25 September 1534), born Giulio di Giuliano de' Medici, was a cardinal from 1513 to 1523 and was Pope from 1523 to 1534.

He was born in Florence one month after his father's death. His father, Giuliano de' Medici, had been assassinated. Although his parents had not had a formal marriage, a canon law loophole allowing for the parents to have been betrothed per sponsalia de presenti meant that Giulio was considered legitimate. He was thus the nephew of Lorenzo the Magnificent, who educated him in his youth. Clement's mother, Fioretta Gorini, also died leaving him an orphan.

Giulio was made a Knight of Rhodes and Grand Prior of Capua, and, upon the election of his cousin Giovanni de' Medici to the pontificate as Leo X (1513–21), he soon became a powerful figure in Rome. Upon his cousin's accession to the papacy, Giulio became his principal minister and confidant, especially in the maintenance of the Medici interest at Florence as archbishop of that city. On 23 September 1513, he was made cardinal and he was consecrated on 29 September. He had the credit of being the main director of papal policy during the whole of Leo X's pontificate, especially as cardinal protector of England. He was also the titular Bishop of Worcester in the county of Worcestershire in England as Administrator or the See of Worcester.

Pope Clement XI (23 July 1649 – 19 March 1721), born Giovanni Francesco Albani, was Pope from 1700 until his death in 1721.

Albani was born in Urbino, into a noble family that had established itself there from northern Albania in the 15th century and were originally soldiers of Scanderbeg against the Ottoman Empire. During his reign as a Pope the famous Illyricum Sacrum was commissioned, and today it is one of the main sources of the field of Albanology, with over 5000 pages divided in several volumes written by Daniele Farlati and Dom. Coletti.

He was governor of Rieti and Urbino, and was created Cardinal-Deacon of S. Maria in Aquiro by Pope Alexander VIII. He succeeded as Pope on 23 November 1700.

Soon after his accession, the War of Spanish Succession broke out.

Despite initially holding an ambiguous neutrality, Clement was later forced to name Charles, Archduke of Austria, as King of Spain, since the imperial army had conquered much of northern Italy and was threatening Rome itself (January 1709).

Sebastiano del Piombo (c. 1485 – June 21, 1547), byname of Sebastiano Luciani, was an Italian Renaissance-Mannerist painter of the early 16th century famous for his combination of the colors of the Venetian school and the monumental forms of the Roman school.

Sebastiano del Piombo belongs to the painting school of his native city, Venice, but was active for a large portion of his career in Rome. At first a musician, chiefly a soloist on the lute, he was in great request among the Venetian nobility. He soon showed a turn for painting, and became a pupil of Giovanni Bellini and afterwards of Giorgione, whose influence is apparent in his works. Some of Sebastiano's works were indeed confused with Giorgione's, i.e. the Salomè of 1510.

His first painting of note was done for the church of San Giovanni Crisostomo, Venice, and is so closely modeled on the style of Giorgione that in its author's time it often passed for the work of that master.

It represents Saint John Chrysostom reading aloud at a desk, a grand Magdalene in front, and two other female and three male saints.

Pope Clement XIII (7 March 1693 – 2 February 1769), born Carlo della Torre di Rezzonico, was Pope from 16 July 1758 to 2 February 1769.

He was born to a recently ennobled family of Venice, received a Jesuit education in Bologna and became a Cardinal-Deacon of San Nicola in Carcere in 1737. Previously he had filled various important posts in the Curia and had been bishop of Padua since 1743; during his tenure as bishop of Padua he visited all the parishes in the diocese, the first bishop to do that for 50 years. He became pope on 6 July 1758. In the same year the Rezzonico family were celebrating Ludovico Rezzonico's marriage into the powerful Savorgnan family. The son of the man who bought the unfinished palace on the Grand Canal (now Ca' Rezzonico) and finished its construction, Carlo the pontiff was notorious for his rampant nepotism.