Aspendos or Aspendus (Greek Άσπενδος) was an ancient Greco-Roman city in Antalya province of Turkey. It is located 7 kilometres (4.3 mi) northeast of central Serik.

Aspendus was an ancient city in Pamphylia, Asia Minor, located about 40 km east of the modern city of Antalya, Turkey. It was situated on the Eurymedon River about 16 km inland from the Mediterranean Sea; it shared a border with, and was hostile to, Side. According to later tradition, the (originally non-Greek) city was founded around 1000 BC by Greeks who may have come from Argos. The wide range of its coinage throughout the ancient world indicates that, in the 5th century BC, Aspendus had become the most important city in Pamphylia. At that time the Eurymedon River was navigable as far as Aspendus, and the city derived great wealth from a trade in salt, oil, and wool.

Aspendos did not play an important role in antiquity as a political force. Its political history during the colonization period corresponded to the currents of the Pamphylian region. Within this trend, after the colonial period, it remained for a time under Lycian hegemony. In 546 B.C. it came under Persian domination. The face that the city continued to mint coins in its own name, however, indicates that it had a great deal of freedom even under the Persians.