Karnes City is a city in Karnes County, Texas, United States. The population was 3,457 at the 2000 census. It is the county seat of Karnes County. The town was named after Henry Karnes of the Texas Revolution. Karnes is some twenty-five miles south of Floresville on U.S. Highway 181.

In 1893, the county seat was moved from Helena to Karnes City.

Karnes City is located at 28°53′N 97°54′W / 28.883°N 97.9°W / 28.883; -97.9 (28.8882, -97.9013).

According to the United States Census Bureau, the city has a total area of 2.1 square miles (5.4 km²) all land.

Karnes City is about 60 miles (97 km) southeast of San Antonio.

As of the census of 2000, there were 3,457 people, 1,007 households, and 720 families residing in the city. The population density was 1,627.6 people per square mile (629.6/km²). There were 1,180 housing units at an average density of 555.6 per square mile (214.9/km²). The racial makeup of the city was 71.13% White, 5.67% African American, 0.32% Native American, 0.58% Asian, 19.47% from other races, and 2.83% from two or more races. Hispanic or Latino of any race were 63.87% of the population.

Texas (ⁱ/ˈtɛksəs/) (Alibamu: Teksi ) is the second most populous and the second most extensive of the 50 United States, and the most extensive state of the 48 contiguous United States. The name, based on the Caddo word "Tejas" meaning "friends" or "allies", was applied by the Spanish to the Caddo themselves and to the region of their settlement in East Texas. Located in the South Central United States, Texas shares an international border with the Mexican states of Chihuahua, Coahuila, Nuevo León, and Tamaulipas to the south, and borders the US states of New Mexico to the west, Oklahoma to the north, Arkansas to the northeast, and Louisiana to the east. Texas has an area of 268,820 square miles (696,200 km²), and a growing population of 25.7 million residents.

During the Spanish colonial rule, the area was officially known as the Nuevo Reino de Filipinas: La Provincia de Texas. Antonio Margil de Jesús was known to be the first person to use the name in a letter to the Viceroy of Mexico in July 20, 1716. The name was not popularly used in daily speech but often appeared in legal documents until the end of the 1800s.