Silistra (Bulgarian: Силистра, pronounced [siˈlistrɐ], historically Bulgarian: Дръстър, Drastar [ˈdrɤstəɐr]) is a port city of northeastern Bulgaria, lying on the southern bank of the lower Danube at the country's border with Romania. Silistra is the administrative centre of the Silistra Province and one of the important cities of the historical region of Southern Dobrudzha. As of February 2011, the town has a population of 35,607 inhabitants.

Silistra is a major cultural, industrial, transportation, and educational center of northeastern Bulgaria. There are many historical landmarks including a Roman tomb, remains of the Medieval fortress, an Ottoman fort, and an art gallery.

Silistra is in the northeastern part of Bulgaria on the right bank of the Danube River. It is located in the Bulgarian part of Dobrudzha.

The municipality of Silistra covers an area of 516 km² and includes the city and 18 villages. The area of the city-proper is 27.159 km². The total population of the municipality, as of February 2011, is 50,448 of which 35,607 live in the city.