Opoho is a suburb of the New Zealand city of Dunedin. It sits on the western flank of Signal Hill, New Zealand, 3 kilometres (1.9 mi) to the northeast of the city centre, overlooking North East Valley and the Dunedin Botanic Gardens.

Opoho is one of Dunedin's more prestigious residential suburbs however still has somewhat mixed demographics, containing student flats, significant numbers of elderly citizens, and the houses of many in the academic community. There was a former retail area in the southern part of Signal Hill Road, but this has long gone and the area is now largely occupied by student flats. Above the suburb sits the Centennial Lookout, a memorial built on the top of Signal Hill to mark the centenary of New Zealand in 1940. Impressive views over the city can be gained from here.

At the time of the 2006 census, the permanent population was 1,242, a decrease of 18 since 2001.

Opoho takes its name from the small stream, Opoho Creek (also known as Stony Creek). This stream runs south along the western flank of Signal Hill, past Logan Park High School in Dunedin North, before being diverted through culverts and flowing into the Water of Leith close to it outflow into the Otago Harbour. Opoho is a Māori word, simply meaning "The place of Poho", Poho being an 18th-century Ngati Wairua chief who lived close to the stream's outflow, which at that time was into Pelichet Bay (the bay has since been reclaimed and is now part of Logan Park).