Roanoke is an independent city in the Mid-Atlantic U.S. state of Virginia and is the tenth-largest city in the Commonwealth. It is located in the Roanoke Valley of the Roanoke Region of Virginia. The population within the city limits was 97,032 as of 2010. It is the largest municipality in Southwest Virginia, and is the principal municipality of the Roanoke Metropolitan Statistical Area (MSA). In 2009 the Roanoke MSA had an estimated population of 303,418 residents. It is composed of the independent cities of Roanoke and Salem, and the counties of Botetourt, Craig, Franklin and Roanoke. Bisected by the Roanoke River, Roanoke is the commercial and cultural hub of much of the surrounding area of Virginia and Southwest Virginia.

The town first called Big Lick was established in 1852 and chartered in 1874. It was named for a large outcropping of salt which drew the wildlife to the site near the Roanoke River. In 1882 it became the town of Roanoke, and in 1884 it was chartered as the independent city of Roanoke. The name Roanoke is said to have originated from an Algonquian word for shell "money". This was also the name of the river that bisected it (probably where shells had come from) and the county. The city grew frequently through annexation through the middle of the twentieth century. The last annexation was in 1976. The state legislature has since prohibited cities from annexing land from adjacent counties. Roanoke's location in the Blue Ridge Mountains, in the middle of the Roanoke Valley between Maryland and Tennessee, made it the transportation hub of western Virginia and contributed to its rapid growth.

Virginia (ⁱ/vərˈdʒɪnjə/), officially the Commonwealth of Virginia, is a U.S. state located in the South Atlantic region of the United States. Virginia is nicknamed the "Old Dominion" and sometimes the "Mother of Presidents" after the eight U.S. presidents born there. The geography and climate of the Commonwealth are shaped by the Blue Ridge Mountains and the Chesapeake Bay, which provide habitat for much of its flora and fauna. The capital of the Commonwealth is Richmond; Virginia Beach is the most populous city and Fairfax County the most populous political subdivision. The Commonwealth's population is over eight million.

The area's history begins with several indigenous groups, including the Powhatan. In 1607 the London Company established the Colony of Virginia as the first permanent New World English colony. Slave labor and the land acquired from displaced Native American tribes each played a significant role in the colony's early politics and plantation economy. Virginia was one of the 13 Colonies in the American Revolution and joined the Confederacy in the American Civil War, during which Richmond was made the Confederate capital and Virginia's northwestern counties separated to form the state of West Virginia. Although the Commonwealth was under conservative single-party rule for nearly a century following Reconstruction, both major national parties are competitive in modern Virginia.