The University of Texas at San Antonio (UTSA) is a state university in San Antonio, Texas, USA. With an enrollment of more than 30,000 students, it is the third-largest of nine universities and six health institutions in the University of Texas System and the eighth-largest in Texas.

The university serves the San Antonio metropolitan area and the South Texas region through three campuses: Main Campus, Downtown Campus in Downtown San Antonio, and Hemisfair Park Campus (Institute of Texan Cultures). The Main Campus, located 15 miles northwest of Downtown San Antonio, is on 600 acres (2.4 km²), at the intersection of Interstate 10 and Loop 1604 near the northern edge of San Antonio, Texas, in Bexar County.

The University of Texas at San Antonio offers 133 undergraduate, 49 graduate and 22 doctoral programs.

The University of Texas at San Antonio was founded on June 5, 1969 by Governor Preston Smith. In 1970, the University of Texas Board of Regents appointed the university's first president, Arleigh B. Templeton, who served from 1970 to 1972, and received a land donation of 600 acres (2.4 km²) in northwest San Antonio for the site of UTSA. Architects Ford, Powell and Carson Inc. were assigned to design a master plan for the university. Although the university was established in 1970, students temporarily attended class at the Koger Center, which also housed administrative offices until 1975, when construction on the northwest San Antonio campus was completed. UTSA began with five colleges: Business, Fine and Applied Arts, Humanities and Social Sciences, Multidisciplinary Studies and Science and Mathematics.