The City of San Pablo (Filipino: Lungsod ng San Pablo), a first class city in the province of Laguna, Philippines, is one of the country's oldest cities. The City of San Pablo lies in the southern portion of Laguna province. This city is otherwise known as the "City of Seven Lakes" - Seven Lakes of San Pablo, (Filipino: Lungsod ng Pitong Lawa) because it has 7 lakes, Seven Lakes of San Pablo: Lake Sampaloc - Lake Sampalok, Lake Palakpakin, Lake Bunot, Lakes Pandin and Yambo - The twin lake: Lake Pandin and Lake Yambo, Lake Muhikap, and Lake Calibato. By land area, it is the largest in the province of Laguna. By population, it ranks fifth in the province of Laguna.

San Pablo City was once part of the Roman Catholic Archdiocese of Lipa - Lipa, Batangas - Batangas province since 1910. On November 28, 1967 it became an independent diocese and became the Roman Catholic Diocese of San Pablo- San Pablo City - Laguna province.

San Pablo City's earliest historical record dates back to pre-Spanish times when four large barrios bounded by Mt. Makiling composed "Sampalok". In 1571, the first Spanish troops under Captain Juan de Salcedo arrived in the upland village of Sampaloc, which became a parish in 1586, and then a municipality in 1647, and was renamed "San Pablo de Los Montes" in honor of Saint Paul the First Hermit. In 1756 it was placed under the jurisdiction of Batangas province but was returned in 1883 to Laguna province.

San Pablo may refer to:

San Pablo (the Spanish equivalent of Saint Paul) is a common toponym in parts of the world where the Spanish language is or was spoken.

Towns, cities, and counties called San Pablo:

Compound names with San Pablo:

Other geographical features called San Pablo: