Antipolo (officially: City of Antipolo, Filipino: Lungsod ng Antipolo) is a city in the Philippines located in the province of Rizal; about 25 kilometres (16 mi) east of Manila. It is the largest city in the Calabarzon Region in terms of population. It is also the seventh most populous city in the country with a population of 633,971 in 2007.

It was converted from a municipality into a component city of Rizal Province on April 4, 1998 under Republic Act No. 8508. A new provincial capitol building was inaugurated in the city in March 2009 to replace the old capitol in Pasig which has long been outside the jurisdiction of Rizal Province; after Pasig was included in Metro Manila in 1975. With the transfer of the provincial government to Antipolo, it is highly favored to be officially designated as the new capital of the province. On March 14, 2011, Antipolo was declared a "highly-urbanized city" by President Benigno Aquino; such proclamation however still needs to be ratified in a plebiscite.