Quagmire may refer to:

Seth Woobury MacFarlane (born October 26, 1973) is an American actor, voice actor, animator, screenwriter, comedian, producer, director and singer. He created the animated sitcom Family Guy and co-created American Dad! and The Cleveland Show, for which he also voices many of the shows' various characters.

A native of Kent, Connecticut, MacFarlane is a graduate of the Rhode Island School of Design, where he studied animation, earning a Bachelor of Fine Arts degree. He was an animator and writer for Hanna-Barbera for several television shows, including Johnny Bravo, Cow and Chicken, Dexter's Laboratory and I Am Weasel, before creating his own series for 20th Century Fox entitled Family Guy in 1999. MacFarlane went on to co-create American Dad! in 2005, and The Cleveland Show in 2009 for Fox. He also went on to serve as executive producer on the Fox sitcom The Winner.

As an actor, he has made guest appearances on shows such as Gilmore Girls, The War at Home and FlashForward. MacFarlane's interest in science fiction and fantasy has led to cameo and guest appearances on Star Trek: Enterprise and voicing the character of Johann Kraus in Guillermo del Toro's Hellboy II: The Golden Army. In 2008, he created his own YouTube series entitled Seth MacFarlane's Cavalcade of Cartoon Comedy. As a singer, MacFarlane has performed at several venues, including Carnegie Hall and the Royal Albert Hall.

Brian Griffin is a character from the animated television series Family Guy. An anthropomorphic dog, he is voiced by Seth MacFarlane and first appeared on television, along with the rest of the family, in a 15-minute short on December 20, 1998. Brian was created and designed by MacFarlane himself. MacFarlane was asked to pitch a pilot to the Fox Broadcasting Company based on The Life of Larry and Larry & Steve, two shorts made by MacFarlane (the second one at Hanna-Barbera for Cartoon Network's "What-A-Cartoon" project) which featured a middle-aged character named Larry and an intellectual dog, Steve. After the pilot was given the green light, the Griffin family appeared on the episode "Death Has a Shadow".

Brian is a member of the Griffin family. He primarily works in the series as a struggling writer attempting essays, books, novels, screenplays and newspaper articles. His appearance was a redesign of the protagonist Steve from MacFarlane's previous animated short films, The Life of Larry & Steve. He has been featured in much of the Family Guy merchandise, including toys, t-shirts, and video games, and has made crossover appearances in the other MacFarlane-produced shows, American Dad! and The Cleveland Show.

Marjorie "Marge" Simpson (née Bouvier) is a fictional main character in the American animated sitcom The Simpsons and part of the eponymous family. She is voiced by Julie Kavner and first appeared on television in The Tracey Ullman Show short "Good Night" on April 19, 1987. Marge was created and designed by cartoonist Matt Groening while he was waiting in the lobby of James L. Brooks' office. Groening had been called to pitch a series of shorts based on Life in Hell but instead decided to create a new set of characters. He named the character after his mother Margaret Groening. After appearing on The Tracey Ullman Show for three seasons, the Simpson family received their own series on Fox, which debuted December 17, 1989.

Marge is the well-meaning and extremely patient matriach of the Simpson family. With her husband Homer, she has three children: Bart, Lisa, and Maggie. Marge is the moralistic force in her family and often provides a grounding voice in the midst of her family's antics by trying to maintain order in the Simpson household. She is often portrayed as a stereotypical television mother and is often included on lists of top "TV moms". She has appeared in other media relating to The Simpsons—including video games, The Simpsons Movie, The Simpsons Ride, commercials, and comic books—and inspired an entire line of merchandise.