The American Mafia (or simply the Mafia or Mob in the United States), is an Italian-American criminal society. Much like the Sicilian Mafia, the American Mafia has no formal name and is a secret criminal society. Its members usually refer to it as Cosa Nostra or by its English translation "our thing" (or "this thing of ours"). The press has also coined the name "National Crime Syndicate" to refer to the entirety of U.S. organized crime, including the Mafia. The Mafia emerged in New York's Lower East Side and other areas of the East Coast of the United States during the late 19th century following waves of Italian immigration, especially from Sicily. It has its roots in the Sicilian Mafia, but is a separate organization in the United States. Neapolitan, Calabrian, and other Italian criminal groups, as well as independent Italian-American criminals, eventually merged with the Sicilians to create the modern pan-Italian Mafia in North America. Today, the American Mafia cooperates in various criminal activities with the Sicilian Mafia and other Italian organized crime groups, such as Camorra, 'Ndrangheta, and Sacra Corona Unita.

Angelo "The Gentle Don" Bruno (born Angelo Annaloro; May 21, 1910 – March 21, 1980) was a Sicilian-American mobster who ran the Philadelphia crime family for two decades. Bruno gained his nickname and reputation due to his preference for conciliation over violence.

Born in Villalba, Sicily, Bruno emigrated to the United States in his teens and settled in Philadelphia. The son of a grocer, Bruno was a close associate of New York Gambino crime family boss Carlo Gambino. Bruno was a cousin of mobster John Simone. Bruno dropped the name Annaloro and replaced it with his paternal grandmother's maiden name, Bruno.

Bruno was married to Sue Maranca and had two children. Bruno owned an extermination company in Trenton, New Jersey, an aluminum products company in Hialeah, Florida, and a share in the Plaza Hotel in Havana, Cuba. Bruno's first arrest was in 1928 for reckless driving. Subsequent arrests included firearms violations, operating an illicit alcohol still, illegal gambling, and receiving stolen property.

John Joseph Gotti, Jr (October 27, 1940 – June 10, 2002) was an American mobster who became the Boss of the Gambino crime family in New York City. Gotti and his brothers grew up in poverty and turned to a life of crime at an early age. Operating out of the Ozone Park neighborhood of Queens, Gotti quickly rose to prominence, becoming one of the crime family's biggest earners and a protégé of Gambino family underboss Aniello Dellacroce.

After the FBI indicted members of Gotti's crew for selling narcotics, Gotti took advantage of growing dissent over the leadership of the crime family. Fearing he and his men would be killed by Gambino crime family Boss Paul Castellano for selling drugs, Gotti organized the murder of Castellano in December 1985 and took over the family shortly thereafter. This left Gotti as the boss of the most powerful crime family in America, one that made hundreds of millions of dollars a year from construction, hijacking, loan sharking, gambling, extortion and other criminal activities. Gotti was the most powerful crime boss during his era and became widely known for his outspoken personality and flamboyant style, which gained him favor with much of the general public. While his peers avoided attracting attention, especially from the media, Gotti became known as the "The Dapper Don" for his expensive clothes and personality in front of news cameras. He was later given the nickname "The Teflon Don" after three high-profile trials in the 1980s resulted in his acquittal, though it was later revealed that the verdicts were the result of jury tampering and juror misconduct. Law enforcement authorities were not impressed with his style or reputation, however, and they continued gathering evidence against Gotti that helped lead to his downfall.