The following is a list of Playboy Playmates of 2010. Playboy magazine names its Playmate of the Month each month throughout the year.

Jaime Faith Edmondson is an American model. She was the Playboy Playmate of the Month for January 2010. Edmondson is a 2002 graduate of Florida Atlantic University with a degree in Criminal Justice. She is a former police officer and Miami Dolphins cheerleader. Edmondson appeared on The Amazing Race 14 with her friend and fellow Miami Dolphins cheerleader Cara Rosenthal. Edmondson and Rosenthal finished in second place and ultimately lost the $1 Million grand prize and the Amazing Race 14 winners' title to Siblings of Tammy & Victor on that season. Edmondson and Rosenthal later returned to participate in The Amazing Race 18 and they were the third team eliminated, finishing in 9th place because of being 1st U-Turned by Kent & Vyxsin and use the 2nd U-Turn on Flight Time & Big Easy on a Double U-Turn. Edmondson appeared in the music video for "This Ain't No Love Song" by Trace Adkins.

Hollin Sue Cullen, professionally known as Holly Madison, (born December 23, 1979) is an American model, showgirl and television personality. She is widely known for being one of Hugh Hefner's girlfriends on the reality television series The Girls Next Door. Madison now has her own reality series Holly's World.

Although not a Playboy Playmate, she has appeared in nude pictorials with her Girls Next Door costars, Bridget Marquardt and Kendra Wilkinson. In 2009, she appeared as a contestant on the eighth season of Dancing with the Stars.

Madison was born in Astoria, Oregon. She has one younger sister, Stephanie, and a younger brother, Joe. Both siblings were featured on season 3 and season 4 episodes of "The Girls Next Door." Her father's work in the timber industry led her family to travel. From ages two through eleven, she lived on Prince of Wales Island, near Ketchikan, Alaska. Her family later moved back to Oregon, this time to St. Helens. She attended Portland State University for two years, majoring in both theater and psychology.