Conessine

Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda,Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H₃ subtype (with an affinity of pK_i = 8.27; K_i = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.

References

↑ Duez, P; Chamart, S; Lejoly, J; Hanocq, M; Zeba, B; Sawadogo, M; Guissou, P; Molle, L (1987). "Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso". Annales pharmaceutiques francaises 45 (4): 307–13. PMID 3445993.

↑ Kumar, N; Singh, B; Bhandari, P; Gupta, A. P.; Kaul, V. K. (2007). "Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL". Chemical & pharmaceutical bulletin 55 (6): 912–4. doi:10.1248/cpb.55.912. PMID 17541193.

↑ Zirihi, G. N.; Grellier, P; Guédé-Guina, F; Bodo, B; Mambu, L (2005). "Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf". Bioorganic & Medicinal Chemistry Letters 15 (10): 2637–40. doi:10.1016/j.bmcl.2005.03.021. PMID 15863333.

This page contains text from Wikipedia, the Free Encyclopedia - https://wn.com/Conessine

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