Khashayar Karimian

Publications

2. Karimian, K.; Risinger, G.E., “An Improved Procedure for the Synthesis of 2-Acetyl-3-(2-methyl-4-aminopyridine-5-yl) methyl-3a-methylperhydrofuro [2,3d] thiazole”, Org. Prep. Inter. 1978, 10, 45.

3. Risinger, G.E.; Karimian, K.; Jungk, S.; Simpson, J., “On the Biosynthesis of Artemisia Ketone and Bakuchiol”, Experientia, 1978, 34, 1121.

4. Karimian, K.; Ganjian, I.; Askari, M., “Evidence for the Involvement of a Tetrahedral Intermediate in H-D exchange of Thiazolium Ion”, Tetrahedron Lett., 1981 , 22, 22581.

5. Karimian, K.; Askari, M.; Farahani, M., Sachinvala, N.; “Am Improved Procedure for the Synthesis 2-Alkylhihydrothiamine Ketones”, Synthesis, 1981 , 48.

6. Karimian, K., Mohtarami, F.; Askari, M., “Mechanism of Base-Catalysed Hydrogen-Deuterium Exchange in Thiazolium Ion: Evidence for the Involvement of a Tetrahedral Intermediate”, J. Chem. Soc. Perkin II, 1981, 1538.

7. Gorgani, M. N-; Karimian, K., “Non-ionic Adsorptive Immobilization of Proteins to Palmityl-Sepharose 4-B”, Eur. J. Biochem, 1982, 123, 401.

8. Askari, M.; Karimian, K., “Conformational Studies of Some Acyclic Tetrasulfides by Molecular Mechanics and MINDO/3 Methods” J. Molecular Structure, 1983, 92, 347.

9. Gorgani, M. N-; Karimian, K., “Enzyme Immobilization on Palmityl-Sepharose” Biotech. Bioeng.”, 1983, 25, 2617.

10. Karimian, K.; Mohanazadeh, F.; Rezai, S.; “Application of Polymer-bound Thiazolium Salts to the Synthesis of Acyloins and Benzoins: Effects of Solvent and Substituents of the Thiazolium Nucleolus” J. Heterocycl. Chem., 1983, 20, 1119.

11. Gorgani, M. N-; Karimian., K.; Massih, A.; “Effect of Salt Concentration on Binding of Proteins to a Non-Ionic Adsorbent” Experientia, 1984, 40, 81.

12. Gorgani, M. N-; Karimian, K., “Interaction of Proteins With Triton X-100-Substituted Sepharose 4-B” Biotech. Bioeng., 1984, 26, 565.

13. Gorgani, M. N-; Karimian, K.; Mohanazadeh, F., “Synthesis, Characterization and Properties of Hexadecyl Silica; A Novel Hydrophobic Matrix for Protein Immobilization” J. Am. Chem. Soc., 1985, 13, 227.

14. Kluger, R.; Stergiopoulos, V.; Gish, G.; Karimian. K., “Chiral Intermediates in Thiamine Catalysis: Resolution and Pyrophosphorylation of Hydroxyethylthiamin” Bioorg. Chem., 1985, 13, 227.

15. Gorgani, M. N-; Karimian, K., “Use of Hexadecy Fractosil as a Hydrophobic Carrier for Adsorptive Immobilization of Proteins” Biotech. Bioeng. 1986, 28, 1037.

16. Karimian, K.; Mohanazadeh, F., “A Convenient Synthesis of 1’-Alkyl- and 1’-Benzylthiazolium Salts”, Synthesis, 1986, 1065.

17. Karimian, K., “A Very Inexpensive NMR Tube Washer”, J. Chem. Education, 1986, 63, 914.

18. Kluger, K.; Karimian, K.; Gish, G.; Pangborn, W.A.; DeTitta, G.T., “Chirality of Intermediates in Thiamine Catalysis: Structure of (+)-2-(1-Hydroxyethy)-3, 4-Dimethyl-5-(2-Hydroxyethyl) thiazolium Iodide, The Absolute Stereochemistry of the Enantiomers of 2-(1-Hydroxyethyl) thiamine, and Enzymatic Reactions of the Diphosphate”, J. Am. Chem. Soc., 1987 , 109, 618.

19. Kluger, R.; Karimian, K.; Kitumara, K., “Chiral Intermediates in Thiamine Catalysis. The Stereochemical Course of Decarboxylation Step in the Conversion of Pyruvate to Acetaldehyde”, J. Am. Chem. Soc., 1987, 110, 63.

20. Bearne, S.L.; Gish, G.; Karimian, K.; Kluger, R., “Direct Selective Phosphorylation of the Primary Hydroxyl Group in Hydroxyethyl Thiamine by Modified Phosphoric Acid-Creosol Solution and Evaluation of the Extension of the Method to Nucleosides”, Bioorg. Chem., 1989, 17, 224.

21. Mirzayans, R.; Enns, L.; Cubitt, S.; Karimian, K.; Radatus, B.; Paterson, M., “Effect of DNA Polymerase Inhibitors on Repair of δ-Ray-Induced DNA Damage in Proliferating (Intact Versus Permeable) Human Fibroblast: Evidence for Probable Differences in the Modes of Action of Aphidicolin and 1-β-D-Arabinofuran Tosylcytosine”, Biochem. Biophys. Acta, 1994, 1227, 92.

22. Mirzayans, R.; Cubitt, S.; Enns, L. Karimian, K.; Radatus, B.; Hirani-Hojatti, S.; Murthy, K.; Paterson, M., “Comparative Genotoxicity of 2,3-b-Cyclocytidine and 1-b-D-Arabinofuranosylcytosine in Human Tumor Cell Lines” Carcinogenesis, 1994, 15, 2319.

23. Tam, T.; Leung-Tong, R.; Li, W.; Karimian, K., “Recent Advances in Proton Pump Inhibitors”, Invest. Drugs, 2000, 3, 1064.

24. Leung-Tong, R.; Li, W.; Tam, T.; Karimian, K., “Thiol-Dependent Enzymes and their inhibitors: A Review”, Curr Med Chem, 2002, 9, 979.

25. Tam, T.; Leung-Tong, R.; Li, W.; Wang, Y.; Karimian, K.; Spino, M., “Iron Chelation Research:Past Present, and Future”, Current Med. Chem. 2003, 10, 983.

26. Leung-Toung, R.; Wodzinska, J.; Li, W.; Lowrie, J.; Kukreja, R.; Desilets, D.; Karimian, K.; Tam, T. F. [1,2,4]-Thiadiazole: A Novel Cathepsin B Inhibitor. Bioorg. Med. Chem. 2003, 11(24), 5529-5537.

27. Tam, T.F.; Leung-Toung, R.; Li, W.; Spino, M.; and Karimian, K. “Medicinal Chemistry and Properties of 1,2,4-Thiadiazoles” Min. Rev Bio-org. Chem. 2005, 5, 367.

28. Leung-Toung,`R.; Tam, T.F.; Zhao, Y.; Simpson, C.D.; Li, W.; Desilets, D.; and Karimian, K. “ Synthesis of 3-Substituted Bicyclic Imidazo[1,2-d] [1,2,4]thiadiazoles and Tricyclic Benzo[4,5]imidazo[1,2-d] [1,2,4]thiadiazoles”, J. Org. Chem., 2005, 70, 6230.

29. Regis Leung-Toung, Yanqing Zhao, Wanren Li, Tim F. Tam, Khashayar Karimian and Michael Spino "Thiol Proteases: Inhibitors and Potential Therapeutic Targets" Curr. Med. Chem. 2006, 13, 547. 30. Hajjizadeh, M.; Jabbari, A.; Heli, H.; Moouavi-Movahedi, A.A.; Shefiee, A.; Karimian, K. “Electrocatalytic Oxidation and Determination of Deferasirox and Deferiprone on Nickel Oxyhydroxide-midified Electrode”, Anal. Biochem., 2007, 10, 1016. 31. Yadegari, H.; Jabbari, A.; Heli, H.; Moosavi-Movahedi, A.A.; Karimian, K.; Khodadadi, A. “Electrocatalytic Oxidation of Deferiprone and its Determination on a Carbon Nanotube Modified Glassy Electrode”, Electrochimica Acta, 2007, 14, 2341 32. Yadegari, H.; Jabbari, A.; Heli, H.; Moosavi-Movahedi, A.A.; Karimian, K. “Electro-oxidation and Determinatiomn of Deferiprone on a Glassy Electrode”, Chem. Anal. 2008, 53, 5. 33. H. Yadegari, A. Jabbari, H. Heli, A. A. Moosavi-Movahedi, K. Karimian, A. Khodadadi, "Electrocatalytic oxidation of deferiprone and its determination on a carbon nanotube modified glassy carbon electrode" Electrochim. Acta 2008, 53, 2907.

34. Hajjizadeh, M.; Jabbari, A.; Heli, H.; Moosavi-Movahedi, A.A.; Shafiee, A.; Karimian, K. "Electrocatalytic oxidation and determination of deferasirox and deferiprone on a nickel oxyhydroxide-modified electrode", Anal. Biochem. 2008, 373, 337 35. Moosavi-Movahedi, A. A.; Mousavy, S. J.; Divsalar, A.; Babaahmadi, A.; Karimian, K.; Shafiee, A.; Kamarie, M.; Poursasan. N.; Farzami, B.; Riazi, G. H.; Hakimelahi, G. H.; Tsai, F.Y.; Ahmad, F.; Amani, M.; Saboury, A. A. "The Effects of Deferiprone and Deferasirox on the Structure and Function of b-Thalassemia Hemoglobin", J. Biomolecular Str. Dynamics, 2009, 27, 1.

36. Karimian, K. "Imidazo[2,1-b]thiazoles and their use as pharmaceuticals" Expert Opinion Therapeutic Patents, 2009, 19, 1.

US Patents

2. Recovery of AZT by guanidine precipitation, US 5,387,677, February 7, 1995.

3. Process for preparing 2,3'-O-cyclocytidine, US 5,399,682, March 21, 1995.

4. Complex of guanidine and AZT, US 5,519,129, May 21, 1996.

5. 5-Halo-2,3'-O-cyclocytidines, US 5,527,782, June 18, 1996.

6. Organosulfonyl salts of 2,3'-O-cyclocytidine, US 5,536,824, July 16, 1996.

7. Process for preparing halogenated 2,3-O-cyclocytidine derivatives, US 5,596,093, January 21, 1997.

8. Process for producing 2,2'-o-cyclonucleosides nucleosides, and analogs thereof, US 5,610,292, March 11, 1997.

9. Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefore, US 5,675,006, October 7, 1997.

10. Thiadiazole compounds useful as proton pump inhibitors, US 5,677,302, October 14, 1997.

11. Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof, US 5,686,612, November 11, 1997.

12. 1,4-Dihydropyridines, N-substituted bicyclic 4-hydropyridines, and bicyclic N-substituted 4,5-dihydropyridines, US 5,723,618, March 3, 1998.

13. Methods for the manufacture of terbinafine, US 5,817,875, October 6, 1998.

14. Methods for the manufacture of amorphous cefuroxime axetil, US 5,847,118, December 8, 1998.

15. Methods for the manufacture of neofazodone, US 5,900,485, May 4, 1999.

16. Methods for the manufacture of quinolone carboxylic acids derivatives and intermediates thereof, US 5,914,401, June 22, 1999.

17. Methods for the manufacture of cetirizine, US 6,046,332, April 4, 2000.

18. Thiadiazole compounds useful as inhibitors of H+ /K+ ATPase, US 6,060,472, May 9, 2000.

19. Process for the manufacture of bis-triazole compounds and intermediates useful in the manufacture thereof having antifungal activity, US 6,063,933, May 16, 2000.

20. Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, thiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefore, US 6,080,860, June 27, 2000.

21. Proton pump inhibitors, US 6,093,738, July 25, 2000.

22. Process for scavenging thiols, US 6,114,537, September 5, 2000.

23. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes, US 6,162,791, December 19, 2000.

24. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof, US 6,245,903, June 12, 2001.

25. Thiadiazole compounds useful as inhibitors of cysteine activity dependent enzymes, US 6,468,977, October 22, 2002.

26. Process to manufacture simvastatin and intermediates, US 6,506,929, January 14, 2003.

27. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof, US RE39,087 E, May 2, 2006.

References

External links