VASP

Viação Aérea São Paulo S/A or VASP was an airline with its head office in the VASP Building on the grounds of Congonhas-São Paulo Airport in São Paulo, Brazil. It had main bases at Congonhas Airport (CGH) and Guarulhos International Airport (GRU), São Paulo.

History

The airline was established on 4 November 1933 by the state government of São Paulo and started operations in 1933. VASP was the first airline to serve the interior of the state of São Paulo (São Paulo-São Carlos-São José do Rio Preto and São Paulo-Ribeirão Preto-Uberaba), with two Monospar ST-4. At the start of the 1930s, it was the only carrier to operate with land planes. At the time this was a real exploit due to the lack of adequate non-coastal airports. Many landing strips were improvised in flat pastures. This insistence on using only land planes led to the building in 1936 of one of the country’s most important airports, Congonhas, located in the city of São Paulo, far from the coast. During its early years, Congonhas Airport was popularly known as Campo da VASP ("VASP's [Air]field").

VASP (disambiguation)

VASP can refer to:

Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Function

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an N-terminal EVH1 domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions cell membranes. In the mid-region of the protein, family members have a proline-rich region that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Interactions

Vasodilator-stimulated phosphoprotein has been shown to interact with Zyxin,Profilin 1 and PFN2.