5-(2-Aminopropyl)-2,3-dihydrobenzofuran (5-APDB, 3-Desoxy-MDA, EMA-4) is a putative entactogen drug of the phenethylamine and amphetamine classes. It is an analogue of the MDA where the heterocyclic 3-position oxygen from the 3,4-methylenedioxy ring has been replaced by a methylene group. 6-APDB is an anlogue of 5-APDB where the 4-position oxygen has been replaced by a methylene instead. 5-APDB was developed by a team led by David E. Nichols at Purdue University as part of their research into non-neurotoxic analogues of MDMA.

In animal studies, 5-APDB's effects generalize most closely to non-stimulant MDMA analogues such as MBDB and MMAI, while producing no substitution for LSD or amphetamine.In vitro studies show that 5-APDB acts as a highly selective serotonin releasing agent (SSRA), with IC₅₀ values of 130 nM, 7,089 nM, and 3,238 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively. In contrast, 6-APDB is more balanced on the three monoamine neurotransmitters and acts more similarly to MDA and MDMA. Anecdotal reports from human users suggest that 5-APDB produces mild empathy but with relatively little euphoria and is accompanied by sedation.^{[citation needed]}

Manic Street Preachers are a Welsh alternative rock band formed in 1986 consisting of James Dean Bradfield (lead vocals, lead guitar), Nicky Wire (bass, lyrics), and Sean Moore (drums, percussion). The band is part of the Cardiff music scene and were at their most prominent during the 1990s. They are colloquially known as "The Manics" or simply "Manics". Manic Street Preachers were originally a quartet but primary lyricist and rhythm guitarist Richey Edwards vanished on 1 February 1995.

In 1992, the Manics released their debut album, Generation Terrorists. Their combination of androgynous glam punk imagery and critical social lyrics about "culture, alienation, boredom, and despair" soon gained them a loyal following and cult status. The band's later albums retained a leftist politicisation and intellectual lyrical style while adopting a broader alternative rock sound.

Following Edwards' disappearance, Bradfield, Moore, and Wire persisted with Manic Street Preachers and went on to gain critical and commercial success, becoming one of Britain's premier rock bands. Altogether, they have garnered eight Top 10 albums, fifteen Top 10 singles, and have reached number one three times with their 1998 This Is My Truth Tell Me Yours album, the 1998 "If You Tolerate This Your Children Will Be Next" single, and the 2000 "The Masses Against the Classes" single.