Gifu Prefecture (岐阜県, Gifu-ken^?) is a prefecture in the Chūbu region of central Japan. Its capital is the city of Gifu.

Located in the center of Japan, it has long played an important part as the crossroads of Japan, connecting the east to the west through such routes as the Nakasendō. During the Sengoku period, many people referred to Gifu by saying, "control Gifu and you control Japan."

The land area that makes up modern-day Gifu became part of the Yamato Court around the middle of the fourth century. Because it is in the middle of the island of Honshū, it has been the site of many decisive battles throughout Japan's history, the oldest major one being the Jinshin War in 672, which led to the establishment of Emperor Temmu as the 40th emperor of Japan.

The area of Gifu Prefecture consists of the old provinces of Hida and Mino, as well as smaller parts of Echizen and Shinano. The name of the prefecture derives from its capital city, Gifu, which was named by Oda Nobunaga during his campaign to unify all of Japan in 1567. The first character used comes from Qishan (岐山), a legendary mountain from which most of China was unified, whereas the second character comes from Qufu (曲阜), the birthplace of Confucius. Nobunaga chose those characters because he wanted to unify all of Japan and he wanted to be viewed as a great mind.