Proscaline, or 4-propoxy-3,5-DMPEA is a psychedelic and hallucinogenic drug, used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs mescaline and escaline.

Proscaline is in a class of compounds commonly known as phenethylamines, and is the 4-propyloxy homologue of mescaline. The full name of the chemical is 4-propyloxy-3,5-dimethoxyphenethylamine.

Proscaline produces psychedelic effects that can last 12 hours.

The mechanism that produces proscaline’s hallucinogenic and entheogenic effects is unknown, though is most likely attributable to 5HT2A and 5HT2C receptor agonism, among others.

Proscaline is virtually unknown on the black market. Limited accounts of proscaline can be found in journal articles, and in the book PiHKAL (Phenethylamines i Have Known And Loved).

Proscaline is unscheduled and unregulated in the United States, however its close similarity in structure and effects to mescaline could potentially subject possession and sale of proscaline to prosecution under the Federal Analog Act.