Arrestin beta 1

Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.

Function

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. Beta-arrestin might also play a role as scaffold protein in the GPCR pathways.

Interactions

Synthesizer

A sound synthesizer (usually abbreviated as "synthesizer" or "synth", also spelled "synthesiser") is an electronic musical instrument that generates electric signals that are converted to sound through instrument amplifiers and loudspeakers or headphones. Synthesizers may either imitate the still existing sounds (instruments, vocal, natural sound, etc.), or generate new electronic timbres not existing before. They are often played with a musical keyboard, but they can be controlled via a variety of other input devices, including music sequencers, instrument controllers, fingerboards, guitar synthesizers, wind controllers, and electronic drums. Synthesizers without built-in controllers are often called sound modules, and are controlled via MIDI or CV/Gate using a controller device.

Synthesizers use various methods to generate signal. Among the most popular waveform synthesis techniques are subtractive synthesis, additive synthesis, wavetable synthesis, frequency modulation synthesis, phase distortion synthesis, physical modeling synthesis and sample-based synthesis. Other less common synthesis types (see #Types of synthesis) include subharmonic synthesis, a form of additive synthesis via subharmonics (used by mixture trautonium), and granular synthesis, sample-based synthesis based on grains of sound, generally resulting in soundscapes or clouds.

Patch Media

Patch.com is an independent US local news and information platform, primarily owned by Hale Global. As of May 2014, Patch operated some 906 local and hyperlocal news websites in 23 U.S. states.Patch Media Corporation is the operator of the service.

History

Patch was founded by Tim Armstrong, Warren Webster and Jon Brod in 2007 after Armstrong said he found a dearth of online information on his hometown of Riverside, Connecticut. The company was then acquired by AOL in 2009 shortly after Armstrong became AOL's CEO. Armstrong told AOL staffers that he recused himself from negotiations to acquire the company and did not directly profit from his seed investment. He instead asked that his seed money be returned to him in the form of AOL stock when it split from Time Warner.

The acquisition occurred on June 11, 2009. AOL paid an estimated $7 million in cash for the news platform as part of its effort to reinvent itself as a content provider beyond its legacy dial-up Internet business. AOL, which split from Time Warner in late 2009, announced in 2010 it would be investing $50 million or more into the startup of the Patch.com network. As part of the acquisition Brod became President of AOL Ventures, Local & Mapping, and Warren Webster became president of Patch.

Pembrokeshire Action To Combat Hardship

Pembrokeshire Action To Combat Hardship (PATCH), formerly Milford Action To Combat Hardship (MATCH), is a British non-profit Christian faith based charitable organisation, founded in June 2008, that aims to help people who are in a financial crisis. They are based in Milford Haven, Pembrokeshire and have other 'bases' in Monkton and Haverfordwest.

It is based on a similar charity in Southampton, SCRATCH.

Aim

PATCH's main aim is to provide short term relief to people who find themselves in a financial crisis, regardless of circumstances. They work on a referral only bases, so only people who are genuinely in need can access their services.

As the name suggests, they currently only operate in the Pembrokeshire area. Although future expansion can not be ruled out based on their past (i.e. Going from just Milford Haven to Pembrokshire as a whole).

Projects

Basics Banks

PATCH was fist started as a 'basics bank' providing non-perishable food along with clothing and household items. The basics bank works on a referral only basis from outside agencies which give vouchers valid for use in the various PATCH basics banks. There are currently three basics banks in Pembrokeshire in Milford Haven, Monkton and Haverfordwest. However, food parcels are held in churches and other locations around the county in order to enable access to the services for those without transport.

Bard the Bowman

Bard the Bowman is a character in J. R. R. Tolkien's The Hobbit. A Man of Laketown and a descendant of the ancient Lords of Dale, Bard manages to kill Smaug, the dragon, after which he becomes king of Dale. Tolkien created the character specifically to kill Smaug, since none of the other protagonists of the story were able to fulfill this role. Bard the Bowman could have been inspired by Wiglaf from Anglo-Saxon poem Beowulf.

Fictional history

Bard is a descendant of Girion, the last lord of the city Dale, which had been destroyed by the dragon Smaug two centuries before the events of The Hobbit, which takes place in year 2941 of the Third Age. He is the captain of a company of archers in Esgaroth (Lake-town), and is tall and grim with black hair. When Smaug attacks Lake-town, Bard is the last of the archers to survive, but the dragon is immune to arrows. However, a thrush speaks to Bard, showing him the weak spot in the dragon's armour in the hollow under Smaug's left breast, which Bilbo had discovered in his conversation with Smaug. He fires his favourite shaft, the family heirloom "Black Arrow", so powerfully that it kills Smaug, who falls in ruin into the lake.

Bard, Aosta Valley

Bard (pron. bar) is a town and comune in the Aosta Valley region of northwestern Italy. It is part of the Unité des communes valdôtaines du Mont-Rose and has a population of 134.

Fort Bard (Italian: Forte di Bard - French: Fort de Bard) is a fortified complex built in the 19th century by the House of Savoy on a rocky prominence above the town. After many years of neglect, it has been completely restored. In 2006 It reopened to tourists as the home for the Museum of the Alps. The fort also has art exhibitions. In the summer, the main courtyard is used to host musical and theatrical performances.

History

Bard lies at the centre of a deep, narrow gorge at the head of the Aosta valley. This strategic point has been inhabited since the Neolithic period as archaeologists have found several large engraved stones around the area. It later became a major route between Celtic Gaul and the Roman world of the Italian peninsula.

Today the town has many buildings dating back to the 16th century. These include the Bishop's House and the House of the Sun Dial. The Dora Baltea is also crossed by a Medieval stone bridge

Bard (disambiguation)

A bard is a minstrel in medieval Scottish, Irish and Welsh societies; and later re-used by romantic writers.

Bard, BARD, The Bard or Bård may also refer to:

People

Organization

Fictional characters

Places