2C-E (2,5-dimethoxy-4-ethylphenethylamine) is a psychedelic and phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin.

It is commonly active in the 10–20 mg range, taken orally or nasally and highly dose-sensitive. Insufflating (administering the chemical nasally) requires a much lower dose, typically not exceeding 10 mg, but this method of consumption elicits a noticeably painful or uncomfortable sensation in the nasal cavity for 10 minutes or so. Shulgin classified 2C-E as a member of the "Magical Half-Dozen" in his book PiHKAL: A Chemical Love Story. Many have reported that the general effects of 2C-E are similar to those of the other psychedelic phenethylamines, but far more intense. Vivid visuals similar to those experienced while under the influence of LSD are common, and many reports indicate that the effects of this particular chemical may be overly intense for those not well experienced with psychedelics.

2,5-Dimethoxy-4-ethylphenethylamine is a colorless oil. Crystalline forms are obtained as the amine salt by reacting the free base with a mineral acid, typically HCl.

Ralph Metzner Ph.D. (born May 18, 1936 in Germany), is an American psychologist, writer and researcher, who participated in psychedelic research at Harvard University in the early 1960s with Timothy Leary and Richard Alpert (later named Ram Dass). Dr. Metzner is a psychotherapist, and Professor Emeritus of psychology at the California Institute of Integral Studies in San Francisco, where he was formerly the Academic Dean and Academic Vice-president.

Dr. Metzner has been involved in consciousness research, including psychedelics, Yoga, meditation and Shamanism for over 45 years. He is a co-founder and President of the Green Earth Foundation, a non-profit educational organization devoted to healing and harmonizing the relationship between humans and the Earth, and a signatory to the 9/11 Truth Statement. Metzner was featured in the 2006 film Entheogen: Awakening the Divine Within, a documentary about rediscovering an enchanted cosmos in the modern world.

He has conducted numerous workshops on consciousness transformation and alchemical divination, both nationally and internationally. He is also a poet and singer-songwriter and has produced one CD.