Glycoprotein 130
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
Characteristics
The members of the IL-6 receptor family all complex with gp130 for signal transduction. For example, IL-6 binds to the IL-6 Receptor. The complex of these two proteins then associates with gp130. This complex of 3 proteins then homodimerizes to form a hexameric complex which can produce downstream signals. There are many other proteins which associate with gp130, such as cardiotrophin 1 (CT-1), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and IL-11. There are also several other proteins which have structural similarity to gp130 and contain the WSXWS motif and preserved cysteine residues. Members of this group include LIF-R, OSM-R, and G-CSF-R.
Rain
I don't feel a thing
and I stopped remembering
The days are just like moments turned to hours
Mother Used to say
if you want, you'll find a way
But mother never danced through fire showers
Walk in the rain, in the rain, in the rain
I walk in the rain, in the rain
Is it right or is it wrong
and is it here that I belong
I don't hear a sound
Silent faces in the ground
The quiet screams, but I refuse to listen
If there is a hell
I'm sure this is how it smells
Wish this were a dream, but no, it isn't
Walk in the rain, in the rain, in the rain
I walk in the rain, in the rain
Am I right or am I wrong
and is it here that I belong
Walk in the rain, in the rain, in the rain
I walk in the rain, in the rain
Why do I feel so alone