CI-1017
CI-1017 is a muscarinic acetylcholine receptor agonist which is selective for and is approximately equipotent at the M1 and M4 receptors, with 20-30-fold lower affinity for the M2, M3, and M5 subtypes It is the (R)-enantiomer of the racemic compound PD-142,505.
In animals CI-1017 improves learning and memory and increases the electrical activity of the hippocampus through activation of the M1 receptor, while minimally producing parasympathetic side effects and only at very high doses. It also inhibits production of amyloidogenic A beta peptide and increases secretion of soluble amyloid precursor protein via stimulation of the M1 receptor as well. Based on these data, it was hypothesized that CI-1017 could not only treat the symptoms of Alzheimer's disease, but could also potentially slow its progression. It was tested in clinical trials for this purpose in the early 2000s but was apparently abandoned for unknown reasons.
References
Podcasts:
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by New Found Glory
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by Gucci Mane
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by Currensy
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by Ina Deter
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by Zao
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by Glenn Miller
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by Queens Of The Stone Age
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by Driller Killer
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by Diesel Boy
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by Retard-O-Bot
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by Shins
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by Zimmer's Hole
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by Blood Stain Child
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by The Shins
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by Jeremih
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by Denison Marrs
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by Kevin Coyne
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by Cleopatra
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by Betzefer
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by Cleopatra Stratan
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by Shamra
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by Xo Icy
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by Da Eisi Is Gay
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by Gruppo Sportivo
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by L.e.p. Bogus Boys
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by Corrina Repp
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by We
2's + 3's
by: New Found GloryI sat and stared at the sky.
I knew I'd find myself there again.
I wonder how else to cope with the air.
The air that brings me this luck.
I'm unlucky, that's just me
Seems what used to be has changed.
And I feel it coming again
I feel it coming with the wind
I feel it coming again
I feel it breaking with the wind
And I know, I won't feel it again if I just played along.
"Stupid games are for stupid people" and they end just like a song.
A song with no beginning, a song that has no meaning.
Just like this one, just like this one...
I sat and stared at the sky.
I knew I'd find myself there again.
I wonder how else to cope with the air.
And I feel it coming again
I feel it coming with the wind
I feel it coming again
I feel it breaking with the wind
And I know, I won't feel it again if I just played along.
"Stupid games are for stupid people" and they end just like a song.
A song with no beginning, a song that has no meaning.