MTEP
3-((2-Methyl-4-thiazolyl)ethynyl)pyridine (MTEP) is a research drug that was developed by Merck & Co. as a selective allosteric antagonist of the metabotropic glutamate receptor subtype mGluR5. Identified through structure-activity relationship studies on an older mGluR5 antagonist MPEP, MTEP has subsequently itself acted as a lead compound for newer and even more improved drugs.
MTEP is both more potent and more selective than MPEP as a mGluR5 antagonist, and produces similar neuroprotective,antidepressant,analgesic, and anxiolytic effects but with either similar or higher efficacy depending on the test used.
MTEP also has similar efficacy to MPEP in reducing the symptoms of morphine withdrawal, and has anti-addictive effects in a variety of animal models, both reducing ethanol self-administration, and also decreasing the addictive effects of nicotine, cocaine and methamphetamine.
References
Podcasts:
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by Moto Boy
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We Are Never Ever Getting Back Together
by: Matty BI remember right when I woke up the first time
My mom had told me she had set it up by lunch time
You were coming over here to play at my house
We needed a play date, I threw up in my mouth
Never thought that I'd be this fed up so soon
'Till you put your hands on all the stuff in my room
Remember how I even made a sign said, "Keep out!"
I'm gone for one minute, I come back you sneak out
Ohhh you know just how to make me crazy
Ohhh this time I'm telling you I'm telling you
We are never ever ever getting back together
We are never ever ever getting back together
You go talk to your mom talk to my mom talk to me
But we are never ever ever ever getting back together
I'm really miss how immature you are
Working half an hour to make sure I fall
Over when we have to watch TV together
I'm come in, you trip me, spill popcorn, then feathers
Ohhh you know just how to make me crazy
Ohhh this time I'm telling you I'm telling you
We are never ever ever getting back together
We are never ever ever getting back together
You go talk to your mom talk to my mom talk to me
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