Depfa Bank plc is a Dublin-based German-Irish bank. It provides financial services to the public sector and also provides financing for larger infrastructure projects. The name derivates from Deutsche Pfandbriefbank.

Depfa Bank was established in 1922 under auspices of the Prussian government, and was asked to provide financing for residential construction projects. Its more recent history began in 1950s, when the bank become a federally owned corporation, and was to provide for a wide range of residential mortgages. When the corporation lost its tax-free status in the 1970s, it entered the commercial lending industry, becoming the largest German underwriter of public covered bonds. The bank was privatized in 1990, and obtained a FSE listing in 1991.

At the end of the 1990s, the bank went through a legal restructuring, which led the bank to move its headquarters to the IFSC in Dublin, Ireland. In 2002 the Irish government specifically legislated for it. Depfa Bank was purchased by German mortgage giant Hypo Real Estate a subsidiary of Bayerische Hypo- Und Vereinsbank AG in October 2007. The bank ran into liquidity problems in 2008 as a result of the economic and financial turmoil in the United States. At the same time banking supervision in Ireland was very weak, soon to be proved by the 2008–2010 Irish banking crisis.