JZ-IV-10 is a piperidine derivative related to nocaine which is a highly potent triple reuptake inhibitor (SNDRI). The eugeroic modafinil, was used as a lead to fuel these compounds' discovery (J. Zhou, et al. 2004). Although it turns out that the QSAR of the pharmacophoric elements do not appear to be strongly similar. The other isomers were also prepared, although they are weaker than the R,S probes invented in the current study (R. He, et al. 2005).

Upon treatment of the ligands with (H₂O₂ + AcOH) the sulfur atom is oxidized. The resultant molecules then lose most of their potency. This is not a major concern though (c.f. cimetidine, ranitidine). Little has been reported about the SAR of modafinil itself, and it is interesting to consider how these new findings could be applied retrospectively. The NRI selective molecules were employed as brain imaging agents to unravel details about the NE transporter. NRIs are important probes, but they do not function as robust reinforcers.

Terius Youngdell Nash (Born September 20, 1977), better known by his stage name The-Dream, is an American singer-songwriter and record producer. He is known for co-writing chart topping hits such as "Baby" for Justin Bieber, "Umbrella" for Rihanna and "Single Ladies (Put a Ring on It)" for Beyoncé, as well as for his three solo albums, Love Hate, Love vs. Money, and Love King.

Terius Nash was born in Rockingham, North Carolina and moved with his mother, Reva Nash, to Atlanta at the age of 3. He played trumpet, drums, and guitar as a child. His mother died in 1992 when Nash was fifteen years old, an event which would inspire him to write songs. He states that the death of his mother gave him a "soft spot" for women, which he credits to his desire to write songs about female empowerment such as Rihanna's "Umbrella". He moved in with his grandfather, a concrete mason who instilled a strong work ethic in young Nash. Of his grandfather, Nash recalls "He came out of a bad time for blacks in the South, but even though we lived in the hood, we had a boat, some cars and a house that was paid for. So I’ve always had a different outlook on life. There’s nothing I can’t do."

Shawn Corey Carter (born December 4, 1969), better known by his stage name Jay-Z, is an American rapper, songwriter, record producer, entrepreneur, and occasional actor. He is one of the most financially successful hip hop artists and entrepreneurs in America, having a net worth of over $450 million as of 2011.He has sold approximately 50 million albums worldwide, while receiving fourteen Grammy Awards for his musical work, and numerous additional nominations. He is consistently ranked as one of the greatest rappers of all-time. He was ranked #1 by MTV in their list of The Greatest MCs of All-Time in 2006. Two of his albums, Reasonable Doubt (1996) and The Blueprint (2001) are considered landmarks in the genre with both of them being ranked in Rolling Stone magazine's list of the 500 greatest albums of all time. Blender included the former on their 500 CDs You Must Own Before You Die.

Jay-Z co-owns the 40/40 Club, is part-owner of the NBA's Brooklyn Nets and is also the creator of the line Rocawear. He is the former CEO of Def Jam Recordings, one of the three founders of Roc-A-Fella Records, and the founder of Roc Nation. As an artist, he holds the record for most number one albums by a solo artist on the Billboard 200 with eleven. Jay-Z also has had four number ones on the Billboard Hot 100, one as lead artist.

Zane Lowe (born Alexander Zane Reid Lowe on 7 August 1973) also known as 'Zipper', is a radio DJ and television presenter. He was born in New Zealand and grew up in Auckland, where he was a presenter on the local music station Max TV, before moving to England. He presents BBC Radio 1's evening show, where he plays a variety of alternative music, including rock, punk, dance, drum and bass, and hip hop. He was also the presenter of the MTV Rocks show Gonzo, having been a former VJ on MTV since 1997, where he presented Brand:New. Lowe currently resides in London with his wife and two sons, Jackson and Lucius. He is best known for his boundless sycophancy.

Lowe's radio show can be heard on Mondays to Thursdays from 7pm to 9pm. Past and present features on his show have included:

Lowe's method of DJing is rather enthusiastic and fast-paced, similar to many hip hop DJs, with samples of radio stations, interview clips and Radio 1 stings thrown in between songs, along with the occasional sound of Lowe singing along to the music.

Kendrick Lamar Duckworth (born June 17, 1987), simply known as Kendrick Lamar, is an American rapper and songwriter from Compton, California currently signed to Top Dawg, Aftermath and Interscope. He first gained major attention after the release of his 2010 mixtape Overly Dedicated. In 2011, his album Section.80, released exclusively through iTunes, instantly ranked as one of the top digital hip hop releases of the year. Lamar has amassed a large internet following, is a member of hip hop collective Black Hippy, along with Jay Rock, Schoolboy Q and Ab-Soul, and has worked with Snoop Dogg, Dr. Dre, Wiz Khalifa, Game, Drake, Busta Rhymes and Tech N9ne among other popular artists.