Selective serotonin re-uptake inhibitors or serotonin-specific reuptake inhibitor (SSRIs) are a class of compounds typically used as antidepressants in the treatment of depression, anxiety disorders, and some personality disorders.

SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin in the synaptic cleft available to bind to the postsynaptic receptor. They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having only weak affinity for the noradrenaline and dopamine transporter.

The efficacy of SSRIs in mild or moderate cases has been disputed. A 2010 meta-analysis states that "The magnitude of benefit of antidepressant medication compared with placebo ... may be minimal or nonexistent, on average, in patients with mild or moderate symptoms. For patients with very severe depression, the benefit of medications over placebo is substantial." This analysis discarded a great majority of FDA-approved antidepressant studies^{[citation needed]}, including those that used placebo washout periods typically used as controls.

The Guns are a four-piece rock band from South Wales. The current line-up consists of Alex Wiltshire (vocals and guitar), Adam Turner (lead guitar), Tom Coburn (bass guitar) and Chris 'Stix' Davies (drums). The band have stated that they would like to remain independent and have turned down numerous record deals as a result of that. As of 2012, The Guns have released two EPs, and two albums.

After the once popular South Wales band When Reason Sleeps, which contained the frontman for fellow Welsh band The Blackout, Sean Smith, broke up, lead singer Alex Wiltshire set out and recruited Adam Turner on lead guitar, Tom Coburn on bass guitar, and Kob on drums. The Guns were formed, and after a small amount of gigs, they were asked by Pontypridd band Lostprophets to support them during their Liberation Transmission tour, The Guns accepted the offer and went on to play on the main stage at The Full Ponty 2007. Also, during this period The Guns had started work on their debut album With The Guns, and had released a self-titled 3 track CD available through their Myspace and at gigs.