Interstate 16 (I-16), also known as Jim Gillis Historic Savannah Parkway or State Route 404 (SR 404), is an intrastate Interstate Highway located entirely within the state of Georgia, United States. I-16 runs from downtown Macon, at Interstate 75 to downtown Savannah at Montgomery Street (Exit 167B).

The highway carries the unsigned designation of State Route 404, though the state route has a spur that is signed.

I-16 serves as a hurricane evacuation route for Savannah and other coastal areas. The road is designed for contraflow travel with railroad-type gates to block most entrance and exit ramps for the normally eastbound lanes. Some ramps are ungated, apparently for entrance to and exit from the contraflow lanes. Just east of Exit 42 is a crossover to return all westbound traffic to the westbound travel lanes.

Southeast of Macon, I-16 passes through Ocmulgee National Monument but without direct access. Visitors need to first exit at the Colliseum Drive (U.S. Route 80) exit.

The last part of the highway opened up on September 22, 1978, running it through Emanuel County, Candler County, and Bulloch County completing the connection between downtown Macon and Savannah.