The Delta blues is one of the earliest styles of blues music. It originated in the Mississippi Delta, a region of the United States that stretches from Memphis, Tennessee in the north to Vicksburg, Mississippi in the south, Helena, Arkansas in the west to the Yazoo River on the east. The Mississippi Delta area is famous both for its fertile soil and its poverty. Guitar, harmonica and cigar box guitar are the dominant instruments used, with slide guitar (usually on the steel guitar) being a hallmark of the style. The vocal styles range from introspective and soulful to passionate and fiery. Delta blues is also regarded as a regional variation of country blues.

Although Delta blues certainly existed in some form or another at the turn of the 20th century, it was first recorded in the late 1920s, when record companies realized the potential African American market in Race records. The earliest recordings were by the 'major' labels and consist mostly of one person singing and playing an instrument, though the use of a band was more common during live performances. Freddie Spruell is reckoned to be the first Delta blues artist to record, as he waxed "Milk Cow Blues" in Chicago in June 1926. Some of these early recordings were made on 'field trips' to the South by record company talent scouts, but some Delta blues performers were invited to travel to northern cities to record. According to Dixon & Godrich [1981], Tommy Johnson and Ishman Bracey were recorded by Victor on that company's second field trip to Memphis, in 1928. Robert Wilkins was first recorded by Victor in Memphis in 1928, and Big Joe Williams and Garfield Akers also in Memphis (1929) by Brunswick/Vocalion.

Eddie James "Son" House, Jr. (March 21, 1902 (?) – October 19, 1988) was an American blues singer and guitarist. House pioneered an innovative style featuring strong, repetitive rhythms, often played with the aid of slide guitar, and his singing often incorporated elements of southern gospel and spiritual music. House did not learn guitar until he was in his early twenties, as he had been "churchified", and was determined to become a Baptist preacher. He associated himself with Delta blues musicians Charlie Patton and Willie Brown, often acting as a sideman. In 1930, House made his first recordings for Paramount Records during a session for Charlie Patton. However, these did not sell well due to the Great Depression, and he drifted into obscurity. He was recorded by John and Alan Lomax for the Library of Congress in 1941 and '42. Afterwards, he moved north to Rochester, New York, where he remained until his rediscovery in 1964, spurred by the American folk blues revival. Over the next few years, House recorded several studio albums and went on various tours until his death in 1988. His influence has extended over a wide area of musicians, including Robert Johnson, John Hammond, Alan Wilson (of Canned Heat), Bonnie Raitt, The White Stripes, and John Mooney.

Robert Leroy Johnson (May 8, 1911 – August 16, 1938) was an American blues singer and musician. His landmark recordings from 1936–37 display a combination of singing, guitar skills, and songwriting talent that have influenced later generations of musicians. Johnson's shadowy, poorly documented life and death at age 27 have given rise to much legend, including a Faustian myth. As an itinerant performer who played mostly on street corners, in juke joints, and at Saturday night dances, Johnson enjoyed little commercial success or public recognition in his lifetime.

His records sold poorly during his lifetime, and it was only after the first reissue of his recordings on LP in 1961 that his work reached a wider audience. Johnson is now recognized as a master of the blues, particularly of the Mississippi Delta blues style. He is credited by many rock musicians as an important influence; Eric Clapton has called Johnson "the most important blues singer that ever lived." Johnson was inducted into the Rock and Roll Hall of Fame as an "Early Influence" in their first induction ceremony in 1986. In 2003, David Fricke ranked Johnson fifth in Rolling Stone 's list of 100 Greatest Guitarists of All Time.

"The Man" is a slang phrase that may refer to the government or to some other authority in a position of power. In addition to this derogatory connotation, it may also serve as a term of respect and praise.

The phrase "the Man is keeping me down" is commonly used to describe oppression. The phrase "stick it to the Man" encourages resistance to authority, and essentially means "fight back" or "resist", either openly or via sabotage.

The earliest recorded use^{[citation needed]} of the term "the Man" in the American sense dates back to a letter written by a young Alexander Hamilton in September 1772, when he was 15. In a letter to his father James Hamilton, published in the Royal Dutch-American Gazette, he described the response of the Dutch governor of St. Croix to a hurricane that raked that island on August 31, 1772. "Our General has issued several very salutary and humane regulations and both in his publick and private measures, has shewn himself the Man." ^{[dubious – discuss]} In the Southern U.S. states, the phrase came to be applied to any man or any group in a position of authority, or to authority in the abstract. From about the 1950s the phrase was also an underworld code word for police, the warden of a prison or other law enforcement or penal authorities.

McKinley Morganfield (April 4, 1913 – April 30, 1983), known as Muddy Waters, was an American blues musician, generally considered the "father of modern Chicago blues". He was a major inspiration for the British blues explosion in the 1960s, and was ranked No. 17 in Rolling Stone magazine's list of the 100 Greatest Artists of All Time.

Although in his later years Muddy usually said that he was born in Rolling Fork, Mississippi, in 1915, he was actually born at Jug's Corner in neighboring Issaquena County, Mississippi, in 1913. Recent research has uncovered documentation showing that in the 1930s and 1940s he reported his birth year as 1913 on both his marriage license and musicians' union card. A 1955 interview in the Chicago Defender is the earliest claim of 1915 as his year of birth, which he continued to use in interviews from that point onward. The 1920 census lists him as five years old as of March 6, 1920, suggesting that his birth year may have been 1914. The Social Security Death Index, relying on the Social Security card application submitted after his move to Chicago in the mid 1940s, lists him as being born April 4, 1915. Muddy's gravestone lists his birth year as 1915.