F-15,599 is a very potent and highly selective 5-HT_1A receptor full agonist. It displays functional selectivity by strongly activating 5-HT_1A receptors in the prefrontal cortex while having little effect on autoreceptors in the raphe nucleus. As a result, it has been touted as a preferential postsynaptic 5-HT_1A receptor agonist and is being investigated as a novel potential antidepressant.

The McDonnell Douglas (now Boeing) F-15 Eagle is a twin-engine, all-weather tactical fighter designed by McDonnell Douglas to gain and maintain air superiority in aerial combat. It is considered among the most successful modern fighters, with over 100 aerial combat victories with no losses in dogfights. Following reviews of proposals, the United States Air Force selected McDonnell Douglas' design in 1967 to meet the service's need for a dedicated air superiority fighter. The Eagle first flew in July 1972, and entered service in 1976. The F-15 is expected to be in service with the U.S. Air Force past 2025.

Since the 1970s, the Eagle has also been exported to Israel, Japan, and Saudi Arabia. Despite originally being envisioned as a pure air superiority aircraft, the design proved flexible enough that an all-weather strike derivative, the F-15E Strike Eagle, was later developed, and entered service in 1989.

Following studies in 1964–1965, the U.S. Air Force developed requirements for an air superiority fighter in October 1965. Then on 8 December 1965, the Air Force issued a request for proposals (RFP) for the new fighter. The request called for both air-to-air and air-to-ground capabilities. Eight companies responded with proposals. In the following study phase, four of these companies developed some 500 design concepts. Typical designs featured variable-sweep wings, weighed over 60,000 lb (27,200 kg), included a top speed of Mach 2.7 and a thrust-to-weight ratio of 0.75. The designs were not accepted by the Air Force as they compromised fighter qualities for ground attack qualities. Acceptance of the Energy-Maneuverability (E-M) theory by the Air Force led to a change in requirements for improved maneuverability by the spring 1967. The design mission weight was reduced to 40,000 lb (18,100 kg), top speed reduced to Mach 2.3–2.5 and thrust-to-weight ratio increased to 0.97.

David Bowie ( /ˈboʊ.i/ BOH-ee; born David Robert Jones on 8 January 1947) is an English musician, actor, record producer and arranger. A major figure for over four decades in the world of popular music, Bowie is widely regarded as an innovator, particularly for his work in the 1970s. He is known for his distinctive voice and the intellectual depth and eclecticism of his work.

Bowie first caught the eye and ear of the public in July 1969, when his song "Space Oddity" reached the top five of the UK Singles Chart. After a three-year period of experimentation he re-emerged in 1972 during the glam rock era with the flamboyant, androgynous alter ego Ziggy Stardust, spearheaded by the hit single "Starman" and the album The Rise and Fall of Ziggy Stardust and the Spiders from Mars. Bowie's impact at that time, as described by biographer David Buckley, "challenged the core belief of the rock music of its day" and "created perhaps the biggest cult in popular culture." The relatively short-lived Ziggy persona proved merely one facet of a career marked by continual reinvention, musical innovation and striking visual presentation.

Jay Michael Onrait (born August 29, 1974) is a Canadian television personality, sports anchor and humorist. He is the co-host, along with Dan O'Toole, of the 2:00 AM (ET) edition of SportsCentre which loops until noon the next day.

Onrait is a native of Athabasca, Alberta. Onrait briefly attended the University of Alberta upon graduating from high school in 1992. He describes these 2 years as "The Lost Years". He later attended and graduated from Ryerson University in Toronto in 1998 with a Bachelor of Arts in Radio and Television Arts.

Onrait first joined TSN in 1996 as an editorial assistant while attending Ryerson University. He later went on to become sports director at Global TV in Saskatoon and then spent two years as the host of the The Big Breakfast on the A-Channel in Winnipeg. Onrait then joined NHL Network in 2001 as host of both the network's flagship show NHL on the Fly and Molson That's Hockey 2. He moved to TSN in 2002 and since 2003 he has co-hosted SportsCentre alongside Dan O'Toole. In 2006, Onrait began blogging at tsn.ca. Topics have included the Stanley Cup and the NBA, as well as an all-day blog about the NHL trade deadline. His blogs are usually spiced with references to pop culture. In October 2010 he also became the host of the Sportscentre Morning Rush on TSN 2 until it was taken off the air in October 2011.