Mooca (Portuguese pronunciation: [muˈɔka]) from tupi mo-oka, meaning to build houses, is a district in the subprefecture of the same name in the city of São Paulo, Brazil. Mooca today is about to reach the mark of 65,000 inhabitants, spread in 7.7 square kilometres (3.0 sq mi). It is also considered one of the fastest growing districts in the city, experiencing over the last years a boom in the construction industry. Mooca's economy consists of small businesses, some large industries and in the near future, big shopping centres as its ongoing economic growth is becoming more attractive to investors.

The plains where Mooca lies were first settled by ancient Native American communities, such as the Tupi-Guaraní. São Paulo, known in the 16th century as São Paulo de Piratininga, arose from a Jesuit mission, founded in 1554 to convert indigenous populations, and its history is often confused with that of Mooca. In 1567, Portuguese Bandeirantes, or pathfinders, based in the village of São Paulo de Piratininga moved eastwards in their expeditions and that was probably when the region was first explored. Over the centuries, Mooca became an important rural area, containing a number of farms and cottages, dependent on the work of enslaved African-Brazilians. In the 1890s the area was divided into large plots that were put on sale in order to encourage Mooca's development. The district eventually became an important industrial area as the farms gave way to factories and industries towards the beginning of the 20th century. One of the first working-class sections is Vila Maria Zélia in the northern district of Belém. Many of the industrial installations eventually moved out of the city or closed down (even though a number of them are still active) and, much of the industrial zones became residential.