Coordinates: 41°41′59″N 14°36′40″E / 41.6997°N 14.6111°E / 41.6997; 14.6111

Molise (pronounced [moˈliːze]) (Molisano: Mulise) is a region of Southern Italy, the second smallest of the regions. It was formerly (until 1963) part of the region of Abruzzi e Molise (with Abruzzo) and now a separate entity. The region covers 4,438 km² and has a population of about 300,000.

Molise is the newest Italian region, since it was established in 1963, when the region Abruzzi e Molise was split in two. It became effective only in 1970.

Though there is a large Fiat plant (Termoli), the industrial sector is dominated by the building industry with small and medium-sized farms spread widely throughout the region. Another important industry is food processing: pasta, meat, milk products, oil and wine are the traditional products of the region. In the services sector the most important industries are distribution, hotels and catering, followed by transport and communications, banking and insurance. With few exceptions, in all sectors firms are small, and this explains the difficulties encountered when marketing products on a national scale.