Hashemite is the Latinate version of the Arabic: هاشمي‎, transliteration: Hāšimī, and traditionally refers to those belonging to the Banu Hashim, or "clan of Hashim", a clan within the larger Quraish tribe. It also refers to an Arab dynasty whose original strength stemmed from the network of tribal alliances and blood loyalties in the Hejaz region of Saudi Arabia, along the Red Sea.

The Hashemites trace their ancestry from Hashim ibn Abd al-Manaf (died c. 510 AD), the great-grandfather of the Islamic prophet Muhammad, although the definition today mainly refers to the descendants of the prophet's daughter, Fatimah. The early history of the Hashemites saw them in a continuous struggle against the Umayyads for control over who would be the caliph or successor to Muhammad. The Umayyads were of the same tribe as the Hashemites, but a different clan. After the overthrow of the Umayyads, the Abbasids would present themselves as representatives of the Hashemites, as they claimed descent from Abbas ibn Abd al-Muttalib, an uncle of Muhammad. Muhammad's father had died before he was born, and his mother died while he was a child^{[citation needed]}, so Muhammad was raised by his uncle Abu Talib, chief of the Hashemites.

The Sharif of Mecca (Arabic: شريف مكة‎, Sharīf Makkah) or Hejaz (Arabic: شريف الحجاز‎, Sharīf al-Ḥiǧāz) was the title of the former governors of Hejaz and a traditional steward of the holy cities of Mecca and Medina. The term sharif means "noble" in Arabic and is used to describe the descendants of Muhammad's grandson al-Hassan ibn Ali.

The Sharif was charged with protecting the cities and their environs and ensuring the safety of pilgrims performing the Hajj. The title is sometimes spelled Sheriff or Sherif, with the latter variant used, for example, by T. E. Lawrence in Seven Pillars of Wisdom. The common-law political and legal office of sheriff found in some anglophone countries is unrelated.

The office of the Sharifate of Mecca dates back to the late Abbasid era. Since 1201, the Sharifate was held by a member of the Hawashim clan, not to be confused with the larger clan of Banu Hashim to which all Sharifs claim descent. Descendants of this family continued to hold the position until the Twentieth Century on behalf of various Muslim powers including the Ayyubids and the Mamelukes. In 1517, the Sharif acknowledged the supremacy of the Ottoman Caliph, but maintained a great degree of local autonomy. During the Ottoman era, the Sharifate expanded its authority northwards to include Medina, and southwards to the frontiers of 'Asir, and regularly raided Nejd.