The Panchen Lama (Tibetan: པན་ཆེན་བླ་མ, Wylie: pan-chen bla-ma, ZYPY: Bainqên Lama, simplified Chinese: 班禅喇嘛; traditional Chinese: 班禪喇嘛), or Panchen Erdeni (Tibetan: པན་ཆེན་ཨེར་ཏེ་ནི།, ZYPY: Bänqên Erdê'ni; simplified Chinese: 班禅额尔德尼; traditional Chinese: 班禪額爾德尼), is the highest ranking Lama after the Dalai Lama in the Gelugpa (Dge-lugs-pa) lineage of Tibetan Buddhism (this lineage controlled western Tibet from the 16th century until the 1959 Tibetan Rebellion). The present (11th) incarnation of the Panchen Lama is a matter of controversy: the People's Republic of China asserts it is Gyancain Norbu, while the 14th Dalai Lama asserted it was Gedhun Choekyi Nyima on May 14, 1995. The latter vanished from public eye shortly after being named, aged six. Chinese authorities stated that Gedhun had been taken into protective custody from those that would spirit him into exile and is now safe. Tibetans and human rights groups continue to campaign for his release.

The successive Panchen Lamas form a tulku reincarnation lineage which are said to be the incarnations of Amitabha Buddha. The title, meaning "Great Scholar", is a Tibetan contraction of the Sanskrit paṇḍita (scholar) and the Tibetan chenpo (great). The Panchen Lama traditionally lived in Tashilhunpo Monastery (Teshu-lumbo) in Shigatse. From the name of this monastery, the Europeans referred to the Panchen Lama as the Tashi-Lama (or spelled Tesho-Lama or Teshu-Lama).

The Dalai Lama is a high lama in the Gelug or "Yellow Hat" branch of Tibetan Buddhism. The name is a combination of the Sino-Mongolian word далай (dalai) meaning "Ocean" and the Tibetan word བླ་མ་ bla-ma (with a silent "b") meaning "chief, high priest".

In religious terms, the Dalai Lama is believed by his devotees to be the rebirth of a long line of tulkus who are considered to be manifestations of the bodhisattva of compassion, Avalokiteśvara. Traditionally, the Dalai Lama is thought of as the latest reincarnation of a series of spiritual leaders who have chosen to be reborn in order to enlighten others. The Dalai Lama is often thought to be the leader of the Gelug School, but this position belongs officially to the Ganden Tripa, which is a temporary position appointed by the Dalai Lama who, in practice, exerts much influence. The line of Dalai Lamas began as a lineage of spiritual teachers; the 5th Dalai Lama assumed political authority over Tibet.

For certain periods between the 17th century and 1959, the Dalai Lamas sometimes directed the Tibetan government, which administered portions of Tibet from Lhasa. The 14th Dalai Lama remained the head of state for the Central Tibetan Administration ("Tibetan government in exile") until his retirement on March 14, 2011. He has indicated that the institution of the Dalai Lama may be abolished in the future, and also that the next Dalai Lama may be found outside Tibet and may be female. The Chinese government was very quick to reject this and claimed that only it has the authority to select the next Dalai Lama.