The murder of Meredith Kercher occurred in Perugia, Italy, on 1 November 2007. Kercher, aged 21 at the time of her death, was a British university exchange student from Coulsdon, south London. She was found dead on the floor of her bedroom with stab wounds to the throat. Some of her belongings were missing, including cash, two credit cards, two mobile phones, and her house keys.

Rudy Guede, an Ivory Coast native raised in Perugia, was convicted in October 2008 of having sexually assaulted and murdered Kercher, and was sentenced to 30 years, reduced on appeal to 16 years in December 2009. Also tried were Amanda Knox, an American exchange student and flatmate of Kercher, and Knox's then-boyfriend, Raffaele Sollecito, an Italian student. Knox and Sollecito were convicted on charges of sexual assault and murder in December 2009, and sentenced to 26 and 25 years respectively. Their convictions were overturned on appeal in October 2011 by a panel of six jurors and two judges. In an official statement of their grounds for overturning the convictions the judges wrote there was a "material non-existence" of evidence to support the guilty verdicts at the trial. The appeal judges further stated that the prosecution's theory of an association between Sollecito, Knox and Guede was "not corroborated by any evidence" and "far from probable".

Katherine Anne "Katie" Couric (born January 7, 1957) is an American journalist and author. She serves as special correspondent for ABC News, contributing to ABC World News, Nightline, 20/20, Good Morning America, This Week and primetime news specials. Starting on September 6, 2012, she will host Katie, a syndicated daytime talk show produced by Disney-ABC Domestic Television. She has anchored the CBS Evening News, reported for 60 Minutes, and hosted Today and reported for Dateline NBC. She was the first solo female anchor of a weekday evening news program on one of the three traditional USA broadcast networks. Couric's first book, The Best Advice I Ever Got: Lessons from Extraordinary Lives was a New York Times best-seller.

As of May 2012, Couric also has a web show for ABC News, entitled Katie's Take, airing weekly on Yahoo.

Couric was born in Arlington, Virginia, the daughter of Elinor Tullie (née Hene), a homemaker and part-time writer, and John Martin Couric Jr., a public relations executive and news editor at The Atlanta Journal-Constitution and the United Press in Washington, D.C. Her mother was Jewish, but Couric was raised Presbyterian. Couric's maternal grandparents, Bert Hene and Clara L. Froshin, were the children of Jewish immigrants from Germany. In a report for Today, she traced her paternal ancestry back to a French orphan who immigrated to the U.S. in the nineteenth century and became a broker in the cotton business.

Amanda Marie Knox (born July 9, 1987) is an American woman who was accused of the murder of Meredith Kercher in Perugia, Umbria, Italy. She served four years of a 26-year sentence before the murder conviction was overturned on October 3, 2011. Raffaele Sollecito, Knox's boyfriend at the time of the murder, was also accused of the murder and had his conviction overturned on appeal. The jury upheld Knox's calunnia conviction for falsely implicating bar owner Patrick Lumumba. For this Knox was sentenced to three years in prison, which she had already served, and was ordered to pay Lumumba's court costs of about 22,000 euros.

Knox was born in Seattle, Washington, to Edda Mellas, a math teacher, and Curt Knox, a vice president of finance at Macy's. The couple divorced when Knox was a toddler. Knox attended Seattle Preparatory School, from which she graduated in 2005. In 2005 she began studies at the University of Washington.

In 2007 Knox moved to Perugia, Italy, to study Italian, German, and creative writing at the University for Foreigners for one year. She shared a house with Meredith Kercher, a student from England, as well as two Italian women. In mid-October 2007 she began a romantic relationship with an Italian engineering student, Raffaele Sollecito, from Bari, Apulia.

Anderson Hays Cooper (born June 3, 1967) is an American journalist, author, and television personality. He is the primary anchor of the CNN news show Anderson Cooper 360°. The program is normally broadcast live from a New York City studio; however, Cooper often broadcasts live on location for breaking news stories. As of September 2011, he also serves as host of his own eponymous syndicated daytime talk show, Anderson.

Anderson Hays Cooper was born on June 3, 1967, the younger son of the writer Wyatt Emory Cooper and the artist, designer, writer, and heiress Gloria Vanderbilt, and is a great-great-great-grandson of Cornelius Vanderbilt of the prominent Vanderbilt shipping and railroad fortune. Cooper's media experience began early. As a baby, he was photographed by Diane Arbus for Harper's Bazaar. He is also a descendant, through his mother, of Brevet Major General Hugh Judson Kilpatrick who was with Union General William T. Sherman in his March through Georgia.

At the age of 3 Cooper was a guest on The Tonight Show on September 17, 1970, appearing with his mother. At the age of 9, he appeared on To Tell the Truth as an impostor. From age 10 to 13 Cooper modeled with Ford Models for Ralph Lauren, Calvin Klein and Macy's.