The pancreas /ˈpæŋkriəs/ is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, somatostatin, and pancreatic polypeptide, and a digestive organ, secreting pancreatic juice containing digestive enzymes that assist the absorption of nutrients and the digestion in the small intestine. These enzymes help to further break down the carbohydrates, proteins, and lipids in the chyme.

Under a microscope, stained sections of the pancreas reveal two different types of parenchymal tissue. Lightly staining clusters of cells are called islets of Langerhans, which produce hormones that underlie the endocrine functions of the pancreas. Darker-staining cells form acini connected to ducts. Acinar cells belong to the exocrine pancreas and secrete digestive enzymes into the gut via a system of ducts.

The pancreas is a dual-function gland, having features of both endocrine and exocrine glands.

The part of the pancreas with endocrine function is made up of approximately a million cell clusters called islets of Langerhans. Four main cell types exist in the islets. They are relatively difficult to distinguish using standard staining techniques, but they can be classified by their secretion: α cells secrete glucagon (increase glucose in blood), β cells secrete insulin (decrease glucose in blood), δ cells secrete somatostatin (regulates/stops α and β cells), and PP cells or delta, secrete pancreatic polypeptide.

Alfred Matthew "Weird Al" Yankovic (pronunciation: /ˈjæŋkəvɪk/; born October 23, 1959) is an American singer-songwriter, music producer, accordionist, actor, comedian, writer, satirist, and parodist. Yankovic is known for his humorous songs that make light of popular culture and that often parody specific songs by contemporary musical acts. Since his first-aired comedy song in 1976, he has sold more than 12 million albums (as of 2007), recorded more than 150 parody and original songs, and has performed more than 1,000 live shows. His works have earned him three Grammy Awards among nine nominations, four gold records, and six platinum records in the United States. Yankovic's first top ten Billboard album (Straight Outta Lynwood) and single ("White & Nerdy") were both released in 2006, nearly three decades into his career.

Yankovic's success comes in part from his effective use of music video to further parody popular culture, the song's original artist, and the original music videos themselves, scene-for-scene in some cases. He directed later videos himself and went on to direct for other artists including Ben Folds, Hanson, Black Crowes, and The Presidents of the United States of America. In addition to recording his albums, Yankovic wrote and starred in the film, UHF, and television show, The Weird Al Show. He has also made guest appearances on many television shows, in addition to starring in Al TV specials on MTV.