The humerus ( /ˈhjuːmərəs/; ME from Latin humerus, umerus upper arm, shoulder; cf. Gothic ams shoulder, Greek ōmos. Plural: humeri) is a long bone in the arm or forelimb that runs from the shoulder to the elbow.

Anatomically, it connects the scapula and the lower arm (consisting of the radius and ulna), and consists of three sections. The upper extremity consists of a rounded head, a narrow neck, and two short processes (tubercles, sometimes called tuberosities.) Its body is cylindrical in its upper portion, and more prismatic below. The lower extremity consists of 2 epicondyles, 2 processes (trochlea & capitulum), and 3 fossae (radial fossa, coronoid fossa, and olecranon fossa). As well as its true anatomical neck, the constriction below the greater and lesser tubercles of the humerus is referred to as its surgical neck due to its tendency to commonly get fractured, thus often becoming the focus of surgeons.

The deltoid originates on the lateral third of the clavicle, acromion and the crest of the spine of the scapula. It is inserted on the deltoid tuberosity of the humerus and has several actions including abduction, extension, and circumduction of the shoulder. The supraspinatus also originates on the spine of the scapula. It inserts on the greater tubercle of the humerus, and assists in abduction of the shoulder.