Syracuse ( /ˈsɪrəkjuːs/ or local /ˈsɛrəkjuːs/) is a city in and the county seat of Onondaga County, New York, United States, It is the largest U.S. city with the name "Syracuse", and is the fifth most populous city in the state of New York. At the 2010 census, the city population was 145,170, (making it the 167th largest city in the country) and its metropolitan area had a population of 662,577. It is the economic and educational hub of Central New York, a region with over a million inhabitants. Syracuse is also well-provided with convention sites, with a downtown convention complex and, directly west of the city, the Empire Expo Center, which hosts the annual Great New York State Fair. The city derives its name from Siracusa, a city on the eastern coast of the Italian island of Sicily.

The city has functioned as a major crossroads over the last two centuries, first between the Erie Canal and its branch canals, then of the railway network. Today, Syracuse is located at the intersection of Interstates 81 and 90, and its airport is the largest in the region. Syracuse is home to Syracuse University, a major research university; the Upstate Medical University and Hospital, the city's largest employer; and several smaller colleges and professional schools. In 2010 Forbes rated Syracuse 4th in the top 10 places to raise a family.

New York (/njuː ˈjɔrk/; locally IPA: [nɪu ˈjɔək] or [nuː ˈjɔɹk] ( listen)) is a state in the Northeastern region of the United States. New York is the 27th most extensive, the 3rd most populous, and the 7th most densely populated of the 50 United States. New York is bordered by New Jersey and Pennsylvania to the south, and by Connecticut, Massachusetts and Vermont to the east. The state has a maritime border with Rhode Island east of Long Island, as well as an international border with the Canadian provinces of Ontario to the west and north, and Quebec to the north. The state of New York is often referred to as New York State to distinguish it from New York City.

New York City, with a population of over 8.1 million, is the most populous city in the United States. Alone, it makes up over 40 percent of the population of New York state. It is known for its status as a center for finance and culture and for its status as the largest gateway for immigration to the United States. According to the U.S. Department of Commerce, New York City is also a destination of choice for many foreign visitors. Both the state and city were named for the 17th century Duke of York, James Stuart, future James II and VII of England and Scotland.