TP63
Tumor protein p63 also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene.
TP63 also known as the p63 gene was discovered 20 years after the discovery of the p53 tumor suppressor gene and along with p73 constitutes the p53 gene family based on their structural similarity. Despite being discovered significantly later than p53, phylogenetic analysis of p53, p63 and p73, suggest that p63 was the original member of the family from which p53 and p73 evolved.
Function
Tumor protein p63 is a member of the p53 family of transcription factors. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. TP63 encodes for two main isoforms by alternative promoters (TAp63 and ΔNp63). ΔNp63 is involved in multiple functions during skin development and in adult stem/progenitor cell regulation. In contrast, TAp63 has been mostly restricted to its apoptotic function and more recently as the guardian of oocyte integrity. Recently, two new functions have been attributed to TAp63 in heart development and premature aging.
Podcasts:
TP-2
by: R. KellyHit it hard from the back
Roll around on the front
I know you've heard a lot of tracks
But 12 Play is what you want
Just let me call the studio
Then we can go all night
Girl I hope you can hang
Cause I'm horny as hell tonight
Taking off your Secrets with my teeth
Slightly rough to let you know it's about to get kinky
Three
Blind your eyes, then I walk you to my bedroom
Four
Now open your eyes
Surprise you've entered twelve play two
Stop
We need to catch our breath
We've been going for a while
It's been about two hours
And we're still going round for round
The water's getting cold
And the movie's going off
This is how we do in TP-2
Five
I'm about to take you for a ride
Now feel it come inside
Baby it's as hard as a brick
Tell me can you feel this sh, sh, sh
Seven
That's when to slow it down
Cause I'm not ready to
Eight
We're almost at the peak
Cause I'm feeling tingly
Now flew your body like, what (what, what)
It's like diamonds with the cut (cut, cut)
The hottest out of your friends
The way you take it from me
Girl you put it on me like draws
Moaning when you talk
I'm about to tear your shit out
New millennium style
Nine
Lookin' you in your eyes
As I'm about to do that thing
Then on down to your thighs
I'm gonna make you scream
Eleven
Now put your body on top of me
I'm about to grab your waist
Twelve
Now quick before we get to thirteen