The Shire of Campaspe is a Local Government Area in Victoria, Australia. It is located in the northern part of the state. It includes the towns of Girgarre, Echuca, Kyabram, Rochester, Tongala and Rushworth. It has an area of 4,517 square kilometres. In 2006 it had a population of 36,209. It was formed in 1994 from the merger of the City of Echuca, Shire of Deakin, Shire of Rochester, Shire of Waranga, Town of Kyabram and part of the Shire of Rodney.

Campaspe Shire is represented by nine councillors, with three Councillors representing the Echuca Ward and Kyabram-Deakin Ward and one Councillor representing each of the other wards.

Coordinates: 36°21′40″S 144°44′02″E / 36.36111°S 144.73389°E / -36.36111; 144.73389

Campaspe, (or Pancaste) the mistress of Alexander the Great and a prominent citizen of Larissa. She was painted by Apelles, who had the reputation in Antiquity for being the greatest of painters. The episode occasioned an apocryphal exchange that was reported in Pliny's Natural History: seeing the beauty of the nude portrait, Alexander saw that the artist appreciated Campaspe (and loved her) more than he. And so Alexander kept the portrait but presented Campaspe to Apelles. "So Alexander gave him Campaspe as a present, the most generous gift of any patron and one which would remain a model for patronage and painters on through the Renaissance" Robin Lane Fox remarked.

Apelles also used Campaspe as a model for his most celebrated painting of Aphrodite 'rising out of the sea', the iconic Venus Anadyomene, "wringing her hair, and the falling drops of water formed a transparent silver veil around her form".

No Campaspe appears in the five major sources for the life of Alexander. Alexander's modern biographer Robin Lane Fox traces her legend back to the Roman authors Pliny (Natural History), Lucian of Samosata and Aelian's Varia Historia. They would have it that Campaspe was a prominent citizen of Larissa in Thessaly; Aelian surmised that she initiated the young Alexander in love.