Coordinates: 12°46′50″S 45°13′40″E / 12.7806°S 45.2278°E / -12.7806; 45.2278

Mamoudzou is the capital of the French overseas region and department of Mayotte, in the Indian Ocean. Mamoudzou, known as Momoju in the local Shimaore language, is the most populated commune (municipality) of Mayotte. It is located on Grande-Terre (or Mahoré), the main island of Mayotte. The former capital of Mayotte was Dzaoudzi, on the small island of Petite-Terre (or Pamanzi), but Mamoudzou was chosen as the capital in 1977. The island is located in the Mozambique Channel, between northern Mozambique and northern Madagascar.

The commune is composed of 6 villages in addition to its central habitation, also called Mamoudzou. These are: Kawéni, Mtsapéré, Passamainti, Vahibé, Tsoundzou I and Tsoundzou II.

The commune is also subdivided into 3 cantons; Mamoudzou I, Mamoudzou II and Mamoudzou III.