Aco

ACO, AcO, or Aco may refer to:

Organizations

Places

People

Other uses

Aco (musician)

Aco (born February 3, 1977 in Aichi Prefecture, Japan) is a female Japanese singer. She made her debut in 1995 with the pop single "Fuan nano" (不安なの). She is a part of Sony Music Japan. She explores different musical styles, with the albums Absolute Ego and Material displaying Electronica influences. Absolute Ego was produced by ex-Denki Groove keyboardist, Yoshinori Sunahara and The Other Side of Absolute Ego album contains remixes by Tricky, DJ Krush, and Silent Poets.

In 2003, after a two-year hiatus, she enlisted the help of the avant-garde audio-visual performance group portable [k]ommunity for her quieter, more delicate album, Irony. Irony has been called "one of the most beautiful albums to come out of Japan in 2003" with the music compared to an "airy lullaby".

Discography

Studio albums

Compilation albums

Acetoxy group

Acetoxy group, abbreviated AcO or OAc, is a chemical functional group of the structure CH₃-C(=O)-O-. It differs from the acetyl group CH₃-C(=O)- by the presence of one additional oxygen atom. The name acetoxy is the short form of acetyl-oxy.

Functionality

An acetoxy group may be used as a protection for an alcohol functionality in a synthetic route although the protecting group itself is called an acetyl group.

Alcohol protection

There are several options of introducing an acetoxy functionality in a molecule from an alcohol (in effect protecting the alcohol by acetylation):

An alcohol is not a particularly strong nucleophile and, when present, more powerful nucleophiles like amines will react with the above-mentioned reagents in preference to the alcohol.

ACO1

Aconitase 1, soluble is a protein that in humans is encoded by the ACO1 gene.

Function

The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants.

ACO2

Aconitase 2, mitochondrial is a protein that in humans is encoded by the ACO2 gene.

Structure

The secondary structure of ACO2 consists of numerous alternating alpha helices and beta sheets (SCOP classification: α/β alternating). The tertiary structure reveals that the active site is buried in the middle of the enzyme, and, since there is only one subunit, there is no quaternary structure. Aconitase consists of four domains: three of the domains are tightly compact, and the fourth domain is more flexible, allowing for conformational changes. The ACO2 protein contains a 4Fe-4S iron-sulfur cluster. This iron sulfur cluster does not have the typical function of participating in oxidation-reduction reactions, but rather facilitates the elimination of the citrate hydroxyl group by holding the group in a certain conformation and orientation. It is at this 4Fe-4S site that citrate or isocitrate binds to initiate catalysis. The rest of the active site is made up of the following residues: Gln72, Asp100, His101, Asp165, Ser166, His167, His147, Glu262, Asn258, Cys358, Cys421, Cys424, Cys358, Cys421, Asn446, Arg447, Arg452, Asp568, Ser642, Ser643, Arg644, Arg580. Their functions have yet to be elucidated.

Norma Cluster

The Norma Cluster (ACO 3627 or Abell 3627) is a rich cluster of galaxies located near the center of the Great Attractor and is about 68 Mpc (222 Mly) distant. Although it is both nearby and bright, it is difficult to observe because it is located in the Zone of Avoidance, a region near the plane of the Milky Way. Consequently, the cluster is severely obscured by interstellar dust at optical wavelengths. Its mass is estimated to be on the order of 10¹⁵solar masses.

See also

External links

References

Coordinates: 16^h 15^m 32.8^s, −60° 54′ 30″