Anazarbus (med. Ain Zarba; mod. Anavarza) was an ancient Cilician city, situated in Anatolia in modern Turkey, in the present Çukurova (or classical Aleian plain) about 15 km west of the main stream of the present Ceyhan River (or classical Pyramus river) and near its tributary the Sempas Su.

A lofty isolated ridge formed its acropolis. Though some of the masonry in the ruins is certainly pre-Roman, the Suda's identification of it with Cyinda, famous as a treasure city in the wars of Eumenes of Cardia, cannot be accepted in the face of Strabo's express location of Cyinda in western Cilicia.

Under the early Roman empire the place was known as Caesarea, and was the metropolis of Cilicia Secunda. Rebuilt by the emperor Justin I after an earthquake in the 6th century, it became Justinopolis (525); but the old native name persisted, and when Thoros I, king of Lesser Armenia, made it his capital early in the 12th century, it was known as Anazarva.

Its great natural strength and situation, not far from the mouth of the Sis pass, and near the great road which debouched from the Cilician Gates, made Anazarbus play a considerable part in the struggles between the Byzantine Empire and the early Muslim invaders. It had been rebuilt by Harun al-Rashid in 796, refortified at great expense by the Hamdanid Sayf al-Dawla (mid-10th century) but was then sacked by the Crusaders and returned to the Armenians. Most of the remaining fortifications including the Curtain walls and Keep date to this period and were built by the Armenians. The Mamluk Empire of Egypt finally destroyed the city in 1374.