Brimonidine (bri-MOE-ni-deen, brand names Alphagan and Alphagan-P) is a drug used to treat open-angle glaucoma or ocular hypertension.

It acts via decreasing synthesis of aqueous humor, and increasing the amount that drains from the eye through uveoscleral outflow. As a treatment for glaucoma, it is usually given in eyedrop form.

Brimonidine is an α₂ adrenergic agonist.

Alpha 2 agonists, through the activation of a G protein-coupled receptor, inhibit the activity of adenylate cyclase. This reduces cAMP and hence aqueous humour production by the ciliary body.

Peripheral alpha 2 agonist activity results in vasoconstriction of blood vessels (as opposed to central alpha 2 agonist activity that decreases sympathetic tone, as can be seen by the medication clonidine). This vasoconstriction may explain the acute reduction in aqueous humor flow. The increased uveoscleral outflow from prolonged use may be explained by increased prostaglandin release due to alpha adreneric stimulation. This may lead to relaxed ciliary muscle and increased uveoscleral outflow.

Rich Gaspari (born May 16, 1963) is an American former professional bodybuilder from 1980s and early 1990s. Gaspari was inducted into the IFBB Hall of Fame in 2004. Gaspari started his own supplement company Gaspari Nutrition. The company was formed in 2001 and includes the popular bodybuilding supplements "IntraPro", "SuperPump250" and "SizeOn".

In 2011, actor Ryan Phillippe and boxer Shane Mosley presented Gaspari with the Muscle Beach Hall of Fame Award. Gaspari was featured on the cover of the October, 2011 issue of Iron Man (magazine), 23 years after he last appeared on the cover of the magazine.

Gaspari was born in New Brunswick, New Jersey. He is a resident of Jackson Township, New Jersey.