RhoC

RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It is encoded by the gene RHOC.

Mechanism and function

It is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape and motility. RhoC can activate formins such as mDia1 and FMNL2 to remodel the cytoskeleton.

Overexpression of RhoC is associated with cell proliferation and causing tumors to become malignant. It causes degradation and reconstruction of the Extracellular Matrix (ECM) which helps cells escape the tissue they are currently in. It enhances cell motility giving it the ability to become invasive. It has been found to have a direct relationship to advanced tumor stage and metastasis, with increases in stage being related to increases in RhoC expression. RhoC-deficient mice can still develop tumors but these fail to metastasize, arguing that RhoC is essential for metastasis. It has also been found to enhance the creation of angiogenic factors such as VEGF, which is necessary for a tumor to become malignant. In a study by Vega, RhoC was knocked out which resulted in cells spreading out wide in all directions. When RhoC was disabled, the cell's abilities to move in a specific direction and migrate was impaired. It also reduced the cell's speed of movement, because it was difficult, and sometimes impossible, to polarize the cell.

Réunion

Réunion (French: La Réunion, IPA: [la ʁeynjɔ̃]; previously Île Bourbon) is an insular region of France located in the Indian Ocean. It is situated east of Madagascar and about 175 kilometres (109 mi) southwest of Mauritius, the nearest island. As of 2014, its population numbered 844,994 inhabitants.

The island has been inhabited since the 17th century, when people from Europe (mostly France), Madagascar and Africa settled there. Slavery was abolished on 20 December 1848 (a date celebrated yearly on the island), after which indentured workers were brought from South India, among other places. The island became an overseas department of France in 1946.

The local language, spoken by the majority of the population, is Réunion Creole. The official language is French.

Administratively, Réunion is one of the overseas departments of France. Like the other four overseas departments, it is also one of the 18 regions of France, with the modified status of overseas regions, and an integral part of the Republic with the same status as those situated on the European mainland. Réunion is an outermost region of the European Union and, as an overseas department of France, a part of the Eurozone.

Reunion (Star Trek: The Next Generation)

"Reunion" is the 81st episode of the syndicated American science fiction television series Star Trek: The Next Generation, It is the seventh episode of the fourth season.

In the episode, K'Ehleyr returns to the Enterprise to advise Captain Picard, who is chosen to arbitrate the selection of the new Klingon leader from two candidates, Gowron and Duras, one of whom is suspected to be a traitor.

Plot

The starship Enterprise is met by a Klingon Vor'cha class battlecruiser, and Ambassador K'Ehleyr (Suzie Plakson) requests to speak to Captain Picard (Patrick Stewart) on an "urgent matter". When she beams aboard, she brings a young Klingon boy (Jon Paul Steuer); based on his previous romantic experience with K'Ehleyr, Lt. Worf (Michael Dorn) suspects the child is his son. K'Ehleyr warns the senior staff of a power struggle occurring within the Klingon Empire and implores Picard to meet Chancellor K'mpec (Charles Cooper) aboard the battlecruiser. On the Klingon ship, K'mpec acknowledges that he has been poisoned and is slowly dying, and insists that Picard become the Arbiter of Succession and identify his assassin. K'mpec dies shortly afterward. In a private moment, K'Ehleyr confirms to Worf that the Klingon boy is his son, Alexander, and she did not tell Worf for fear he would try to have a deeper relationship with her; Worf, already burdened by his discommendation, fears for Alexander's future, given the stigma of his family name.

Reunion (video game)

Reunion, also known as Merit's Galactic Reunion, is a space strategy video game. It was the Hungarian game developer company Amnesty Design's (now Digital Reality) first game. The game was programmed by János Kistamás, Krisztián Jámbor, and Attila Lendvai (Amiga), István Kiss (DOS). The soundtrack was made by Tamás Kreiner which was the basis of his reputation.

Plot

In the 27th century, centuries of peace have allowed great scientific progress in the development of the first interstellar warp drive. Two research ships, designated Explorer-1 and Explorer-2, are outfitted with the experimental drives and sent to find new planets of colonization. Only Explorer-2 returns to Earth out of the two Explorers. Refitted as a colony vessel, the Explorer-2 is once again ready to embark when, suddenly, peace is disrupted and the humans were ripped apart from each other. At this same time, a planet-wide rebellion stages a great coup and overthrows the Earthen government, throwing the world into chaos and severing the union. The Explorer-2, crewed by a loyalist space crew, barely escapes the rebellion and leaves the Solar System. Years later after the rebellion, the Explorer-2 arrives damaged at its destination and a colony is set up, naming it "New Earth". After many generations of being separated from Earth, the colony is self-sufficient enough to develop a mission only the best can tread: Explore nearby space, research new technologies, harvest resources, develop a space fleet and eventually... reconquer and reunify Earth, leading to the greatest reunion the universe has ever set its eyes on.