Canadian blues refers to the blues and blues-related music (e.g., blues rock) performed by blues bands and performers in Canada. In Canada, there are hundreds of local and regionally-based Canadian blues bands and performers. As well, there is a smaller number of bands or performers that have achieved national or international prominence. These bands and performers are part of a broader Canadian "blues scene" that also includes city or regional blues societies, blues radio shows, and blues festivals.

A small number of Canadian blues bands and artists have achieved national or international prominence by touring across Canada, the US, or Europe, and releasing recordings that have received critical or audience acclaim in Canada and abroad. The performers below are listed according to the decade during which they first achieved national or international prominence.

In late 1950s, US-born rockabilly pioneer Ronnie Hawkins (born 1935) came to Canada, where he became a key player in the 1960s rock and blues scene in Toronto. 4 October 2002 was declared "Ronnie Hawkins Day" by the city of Toronto when Hawkins was inducted into Canada's Walk of Fame, and he was inducted into the Canadian Music Industry Hall of Fame at the Canadian Music Industry Awards in 2004. His pioneering contribution to rockabilly has also been recognized by the Rockabilly Hall of Fame. His 1984 LP, 'Making It Again', earned him a Juno Award for Country Male Vocalist.