Obuasi is a city in southern Ghana and is the capital of Obuasi Municipal, a district, lying south of Kumasi in the Ashanti Region of Ghana. It has a population of 175,043 people (2012 census). On the railway line from Kumasi to Sekondi, it is known for its Obuasi Gold Mine, now one of the ten largest in the world, gold having been mined on the site since at least the seventeenth century.

Tourists can visit the city's mine by arranging with the Public Relations Directorate of AGA. Operated by the Anglo Gold Ashanti (AGA), formerly the Ashanti Gold Company, it was the company's largest mine until the company's merger with the South African company AngloGold.

Obuasi is also noted for the great health care facilities such as AGA Hospital owned by Anglo Gold, and also a private health facility, St. Jude Hospital, owned by Dr. George Owusu-Asiedu. The facility is noted for many successful surgeries and numerous successful births at the maternity division of the hospital run by the former president of the Ghana Midwives Association, Mrs. Priscilla Owusu-Asiedu. Obuasi also has an airstrip, at a nearby village.